Effects of Astragalus membranaceus with Supplemental Calcium on Bone Mineral Density and Bone Metabolism in Calcium-Deficient Ovariectomized Rats
DC Field | Value | Language |
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dc.contributor.author | Kang, Se-Chan | - |
dc.contributor.author | Kim, Hee Jung | - |
dc.contributor.author | Kim, Mi-Hyun | - |
dc.date.available | 2020-02-29T00:46:14Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 0163-4984 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14838 | - |
dc.description.abstract | It has been reported that Astragalus membranaceus, an Asian traditional herb, has an estrogenic effect in vitro. To examine the possible role of A. membranaceus extract with supplemental calcium (Ca) on bone status in calcium-deficient (LCa) ovariectomized (OVX) rats, a total of 48 female rats were divided into six groups: (1) normal control, (2) sham operation with LCa (sham-LCa), (3) OVX with LCa (OVX-LCa), (4) A. membranaceus supplementation with OVX-LCa (OVX-MLCa), (5) Ca supplementation with OVX (OVX-Ca), and (6) A. membranaceus and Ca supplementation with OVX (OVX-MCa). A. membranaceus ethanol extract (500 mg/kg BW) and/or Ca (800 mg/kg BW) were administered orally for 8 weeks along with a Ca-deficient diet. Results revealed that Ca supplementation with or without A. membranaceus extract significantly improved bone mineral density, biomechanical strength, and ash weight of the femur and tibia in OVX rats. High Ca with A. membranaceus combination supplementation significantly increased the ash weight of the femur and tibia and decreased urinary Ca excretion compared with supplementation of Ca alone. Uterine weight was not changed by A. membranaceus administration in OVX rats. These results suggest that A. membranaceus extract combined with supplemental Ca may be more protective against the Ca loss of bone than A. membranaceus or supplementation of Ca alone in calcium-insufficient postmenopausal women. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HUMANA PRESS INC | - |
dc.relation.isPartOf | BIOLOGICAL TRACE ELEMENT RESEARCH | - |
dc.subject | ESTROGEN DEFICIENCY | - |
dc.subject | DIETARY CALCIUM | - |
dc.subject | VITAMIN-D | - |
dc.subject | ISOFLAVONES | - |
dc.subject | MASS | - |
dc.subject | ABSORPTION | - |
dc.subject | EXPRESSION | - |
dc.subject | CARBONATE | - |
dc.subject | EXCRETION | - |
dc.subject | MAGNESIUM | - |
dc.title | Effects of Astragalus membranaceus with Supplemental Calcium on Bone Mineral Density and Bone Metabolism in Calcium-Deficient Ovariectomized Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000312880700010 | - |
dc.identifier.doi | 10.1007/s12011-012-9527-1 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL TRACE ELEMENT RESEARCH, v.151, no.1, pp.68 - 74 | - |
dc.identifier.scopusid | 2-s2.0-84871923207 | - |
dc.citation.endPage | 74 | - |
dc.citation.startPage | 68 | - |
dc.citation.title | BIOLOGICAL TRACE ELEMENT RESEARCH | - |
dc.citation.volume | 151 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kang, Se-Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Astragalus membranaceus | - |
dc.subject.keywordAuthor | Supplemental calcium | - |
dc.subject.keywordAuthor | Bone mineral density | - |
dc.subject.keywordAuthor | Bone metabolism | - |
dc.subject.keywordAuthor | Calcium-deficient | - |
dc.subject.keywordAuthor | OVX rats | - |
dc.subject.keywordPlus | ESTROGEN DEFICIENCY | - |
dc.subject.keywordPlus | DIETARY CALCIUM | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | ISOFLAVONES | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARBONATE | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | MAGNESIUM | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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