Sphingolipid metabolism and obesity-induced inflammation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, S.-C. | - |
dc.contributor.author | Kim, B.-R. | - |
dc.contributor.author | Lee, S.-Y. | - |
dc.contributor.author | Park, T.-S. | - |
dc.date.available | 2020-02-29T01:42:03Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1664-2392 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14960 | - |
dc.description.abstract | Obesity is a metabolic disorder developed by overnutrition and a major cause for insulin resistance and cardiovascular events. Since adipose tissue is one of the major sites for the synthesis and secretion of cytokines, enlarged adipose tissue in obese condition alters inflammatory state leading to pathophysiological conditions such as type 2 diabetes and increased cardiovascular risk. A plausible theory for development of metabolic dysregulation is that obesity increases secretion of inflammatory cytokines from adipose tissue and causes a chronic inflammation in the whole body. Additionally accumulation of lipids in non-adipose tissues elevates the cellular levels of bioactive lipids that inhibit the signaling pathways implicated in metabolic regulation together with activated inflammatory response. Recent findings suggest that obesity-induced inflammatory response leads to modulation of sphingolipid metabolism and these bioactive lipids may function as mediators for increased risk of metabolic dysfunction. Importantly, elucidation of mechanism regarding sphingolipid metabolism and inflammatory disease will provide crucial information to development of new therapeutic strategies for the treatment of obesity-induced pathological inflammation. © 2013 Kang, Kim, Lee and Park. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.relation.isPartOf | Frontiers in Endocrinology | - |
dc.subject | 3 ketosphinganine reductase | - |
dc.subject | adiponectin | - |
dc.subject | C reactive protein | - |
dc.subject | carnitine palmitoyltransferase I | - |
dc.subject | ceramide | - |
dc.subject | ceramide 1 phosphate | - |
dc.subject | ceramide synthase | - |
dc.subject | dihydroceramide desaturase | - |
dc.subject | glucocorticoid | - |
dc.subject | glucose | - |
dc.subject | inducible nitric oxide synthase | - |
dc.subject | insulin receptor substrate 1 | - |
dc.subject | interleukin 10 | - |
dc.subject | interleukin 1beta | - |
dc.subject | interleukin 6 | - |
dc.subject | leptin | - |
dc.subject | monocyte chemotactic protein 1 | - |
dc.subject | neuropeptide Y | - |
dc.subject | peptides and proteins | - |
dc.subject | phosphoprotein phosphatase 2A | - |
dc.subject | plasminogen activator inhibitor 1 | - |
dc.subject | protein kinase B | - |
dc.subject | sphingolipid | - |
dc.subject | sphingosine | - |
dc.subject | sphingosine 1 phosphate | - |
dc.subject | stress activated protein kinase | - |
dc.subject | toll like receptor 4 | - |
dc.subject | triacylglycerol | - |
dc.subject | tumor necrosis factor alpha | - |
dc.subject | unclassified drug | - |
dc.subject | unindexed drug | - |
dc.subject | adipose tissue | - |
dc.subject | apoptosis | - |
dc.subject | atherosclerosis | - |
dc.subject | cardiomyopathy | - |
dc.subject | cell metabolism | - |
dc.subject | cell proliferation | - |
dc.subject | coronary artery disease | - |
dc.subject | disease association | - |
dc.subject | fatty liver | - |
dc.subject | homeostasis | - |
dc.subject | human | - |
dc.subject | hypothalamus | - |
dc.subject | inflammation | - |
dc.subject | insulin resistance | - |
dc.subject | lipotoxicity | - |
dc.subject | nonhuman | - |
dc.subject | obesity | - |
dc.subject | oxidative stress | - |
dc.subject | prevalence | - |
dc.subject | protein expression | - |
dc.subject | protein metabolism | - |
dc.subject | review | - |
dc.subject | signal transduction | - |
dc.subject | vascular disease | - |
dc.title | Sphingolipid metabolism and obesity-induced inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.3389/fendo.2013.00067 | - |
dc.identifier.bibliographicCitation | Frontiers in Endocrinology, v.4, no.JUN | - |
dc.identifier.scopusid | 2-s2.0-84884199327 | - |
dc.citation.title | Frontiers in Endocrinology | - |
dc.citation.volume | 4 | - |
dc.citation.number | JUN | - |
dc.contributor.affiliatedAuthor | Kang, S.-C. | - |
dc.contributor.affiliatedAuthor | Kim, B.-R. | - |
dc.contributor.affiliatedAuthor | Lee, S.-Y. | - |
dc.contributor.affiliatedAuthor | Park, T.-S. | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Cardiomyopathy | - |
dc.subject.keywordAuthor | Ceramide | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Fatty liver | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordPlus | 3 ketosphinganine reductase | - |
dc.subject.keywordPlus | adiponectin | - |
dc.subject.keywordPlus | C reactive protein | - |
dc.subject.keywordPlus | carnitine palmitoyltransferase I | - |
dc.subject.keywordPlus | ceramide | - |
dc.subject.keywordPlus | ceramide 1 phosphate | - |
dc.subject.keywordPlus | ceramide synthase | - |
dc.subject.keywordPlus | dihydroceramide desaturase | - |
dc.subject.keywordPlus | glucocorticoid | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | inducible nitric oxide synthase | - |
dc.subject.keywordPlus | insulin receptor substrate 1 | - |
dc.subject.keywordPlus | interleukin 10 | - |
dc.subject.keywordPlus | interleukin 1beta | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | leptin | - |
dc.subject.keywordPlus | monocyte chemotactic protein 1 | - |
dc.subject.keywordPlus | neuropeptide Y | - |
dc.subject.keywordPlus | peptides and proteins | - |
dc.subject.keywordPlus | phosphoprotein phosphatase 2A | - |
dc.subject.keywordPlus | plasminogen activator inhibitor 1 | - |
dc.subject.keywordPlus | protein kinase B | - |
dc.subject.keywordPlus | sphingolipid | - |
dc.subject.keywordPlus | sphingosine | - |
dc.subject.keywordPlus | sphingosine 1 phosphate | - |
dc.subject.keywordPlus | stress activated protein kinase | - |
dc.subject.keywordPlus | toll like receptor 4 | - |
dc.subject.keywordPlus | triacylglycerol | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | unindexed drug | - |
dc.subject.keywordPlus | adipose tissue | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | atherosclerosis | - |
dc.subject.keywordPlus | cardiomyopathy | - |
dc.subject.keywordPlus | cell metabolism | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | coronary artery disease | - |
dc.subject.keywordPlus | disease association | - |
dc.subject.keywordPlus | fatty liver | - |
dc.subject.keywordPlus | homeostasis | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hypothalamus | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | lipotoxicity | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | prevalence | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein metabolism | - |
dc.subject.keywordPlus | review | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | vascular disease | - |
dc.description.journalRegisteredClass | scopus | - |
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