Laparoscopy assisted versus open distal gastrectomy with D2 lymph node dissection for advanced gastric cancer: Design and rationale of a phase II randomized controlled multicenter trial (COACT 1001)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남병호 | - |
dc.contributor.author | 김영우 | - |
dc.contributor.author | Reim, Daniel | - |
dc.contributor.author | 엄방울 | - |
dc.contributor.author | 유완식 | - |
dc.contributor.author | 박영규 | - |
dc.contributor.author | 류근원 | - |
dc.contributor.author | 이영준 | - |
dc.contributor.author | 윤홍만 | - |
dc.contributor.author | 이준호 | - |
dc.contributor.author | 정오 | - |
dc.contributor.author | 정상호 | - |
dc.contributor.author | 이상억 | - |
dc.contributor.author | 이상호 | - |
dc.contributor.author | 윤기영 | - |
dc.contributor.author | 서경원 | - |
dc.contributor.author | 정호영 | - |
dc.contributor.author | 권오경 | - |
dc.contributor.author | 김태봉 | - |
dc.contributor.author | 이운기 | - |
dc.contributor.author | 박성흠 | - |
dc.contributor.author | 설지영 | - |
dc.contributor.author | 양대현 | - |
dc.contributor.author | 이종석 | - |
dc.date.available | 2020-02-29T01:42:18Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 2093-582X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14971 | - |
dc.description.abstract | Purpose: Laparoscopy-assisted distal gastrectomy for early gastric cancer has gained acceptance and popularity worldwide. However, laparoscopy-assisted distal gastrectomy for advanced gastric cancer is still controversial. Therefore, we propose this prospective randomized controlled multi-center trial in order to evaluate the safety and feasibility of laparoscopy assisted D2-gastrectomy for advanced stage gastric cancer. Materials and Methods: Patients undergoing distal gastrectomy for advanced gastric cancer staged cT2/3/4 cN0/1/2/3a cM0 by endoscopy and computed tomography are eligible for enrollment after giving their informed consent. Patients will be randomized either to laparoscopyassisted distal gastrectomy or open distal gastrectomy. Sample size calculation revealed that 102 patients are to be included per treatment arm. The primary endpoint is the non-compliance rate of D2 dissection; relevant secondary endpoints are three-year disease free survival, surgical and postoperative complications, hospital stay and unanimity rate of D2 dissection evaluated by reviewing the intraoperative video documentation. Discussion: Oncologic safety is the major concern regarding laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Therefore, the non-compliance rate of clearing the N2 area was chosen as the most important parameter for the technical feasibility of the laparoscopic procedure. Furthermore, surgical quality will be carefully reviewed, that is, three independent experts will review the video records and score with a check list. For a long-term result, disease free survival is considered a secondary endpoint for this trial. This study will offer promising evidence of the feasibility and safety of Laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Trial Registration: NCT01088204 (international), NCCCTS-09-448 (Korea). © 2013 by The Korean Gastric Cancer Association. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한위암학회 | - |
dc.relation.isPartOf | Journal of Gastric Cancer | - |
dc.title | Laparoscopy assisted versus open distal gastrectomy with D2 lymph node dissection for advanced gastric cancer: Design and rationale of a phase II randomized controlled multicenter trial (COACT 1001) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.5230/jgc.2013.13.3.164 | - |
dc.identifier.bibliographicCitation | Journal of Gastric Cancer, v.13, no.3, pp.164 - 171 | - |
dc.identifier.kciid | ART001806286 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84885032137 | - |
dc.citation.endPage | 171 | - |
dc.citation.startPage | 164 | - |
dc.citation.title | Journal of Gastric Cancer | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 이운기 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gastrectomy | - |
dc.subject.keywordAuthor | Lymph node excision | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordPlus | C reactive protein | - |
dc.subject.keywordPlus | carcinoembryonic antigen | - |
dc.subject.keywordPlus | interleukin 19 | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | computer assisted tomography | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disease free survival | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | gastrectomy | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | intermethod comparison | - |
dc.subject.keywordPlus | laparoscopy | - |
dc.subject.keywordPlus | lymph node dissection | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | multicenter study | - |
dc.subject.keywordPlus | outcome assessment | - |
dc.subject.keywordPlus | patient safety | - |
dc.subject.keywordPlus | phase 2 clinical trial | - |
dc.subject.keywordPlus | postoperative complication | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | quality of life | - |
dc.subject.keywordPlus | randomized controlled trial | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | scoring system | - |
dc.subject.keywordPlus | stomach cancer | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.