Longitudinal Assessment of Three Serum Biomarkers to Detect Very Early-Stage Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Choi, Jonggi | - |
dc.contributor.author | Kim, Gi-Ae | - |
dc.contributor.author | Han, Seungbong | - |
dc.contributor.author | Lee, Woochang | - |
dc.contributor.author | Chun, Sail | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.date.available | 2020-02-27T03:41:27Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1522 | - |
dc.description.abstract | We aimed to determine the surveillance performance of alpha-fetoprotein (AFP), lectin-reactive AFP (AFP-L3), des-gamma-carboxy prothrombin (DCP), and their combinations for the early detection of hepatocellular carcinoma (HCC) by using prospectively collected longitudinal samples in patients at risk. Among 689 patients with cirrhosis and/or chronic hepatitis B who participated in four prospective studies, 42 HCC cases were diagnosed, selected, and matched with 168 controls for age, sex, etiology, cirrhosis, and duration of follow-up in a 1:4 ratio. Levels of AFP, AFP-L3, and DCP at the time of HCC diagnosis, month -6, and month -12 were compared between cases and controls. Of 42 HCC cases, 39 (93%) had cirrhosis, 36 (85.7%) had normal alanine aminotransferase levels, and 31 (73.8%) had very early-stage HCC (single <2 cm). AFP and AFP-L3 began to increase from 6 months before diagnosis of HCC in cases (P < 0.05), while they remained unchanged in controls. At HCC diagnosis, the area under the receiver operator characteristic curves (AUROCs) for AFP, AFP-L3, and DCP were 0.77, 0.73, and 0.71, respectively. Combining AFP and AFP-L3 showed a higher AUROC (0.83), while adding DCP did not further improve the AUROC (0.86). With the optimal cutoff values (AFP, 5 ng/mL; AFP-L3, 4%), the sensitivity and specificity of AFP and AFP-L3 combination were 79% and 87%, respectively. The sensitivity of ultrasonography was 48.6%, which was increased to 88.6% and 94.3% by adding AFP and AFP + AFP-L3, respectively. Conclusion: Among three biomarkers, AFP showed the best performance in discriminating HCC cases from controls; the AFP and AFP-L3 combination, adopting cutoff values (5 ng/mL and 4%, respectively), significantly improved the sensitivity for detecting HCC at a very early stage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | HEPATOLOGY | - |
dc.subject | CHRONIC HEPATITIS-B | - |
dc.subject | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject | TENOFOVIR DISOPROXIL FUMARATE | - |
dc.subject | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject | ALPHA-FETOPROTEIN LEVELS | - |
dc.subject | VIRUS INFECTION | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | SURVEILLANCE | - |
dc.subject | MANAGEMENT | - |
dc.subject | DIAGNOSIS | - |
dc.title | Longitudinal Assessment of Three Serum Biomarkers to Detect Very Early-Stage Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000466449400012 | - |
dc.identifier.doi | 10.1002/hep.30233 | - |
dc.identifier.bibliographicCitation | HEPATOLOGY, v.69, no.5, pp.1983 - 1994 | - |
dc.identifier.scopusid | 2-s2.0-85061142551 | - |
dc.citation.endPage | 1994 | - |
dc.citation.startPage | 1983 | - |
dc.citation.title | HEPATOLOGY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Han, Seungbong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-B | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | TENOFOVIR DISOPROXIL FUMARATE | - |
dc.subject.keywordPlus | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject.keywordPlus | ALPHA-FETOPROTEIN LEVELS | - |
dc.subject.keywordPlus | VIRUS INFECTION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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