미역 발효추출물의 HCT-15 대장암 세포 사멸 유도 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태윤 | - |
dc.contributor.author | 한효상 | - |
dc.contributor.author | 이영종 | - |
dc.date.available | 2020-02-29T02:44:41Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15396 | - |
dc.description.abstract | Objectives : To study the apoptosis effects of fermented Undaria pinnatifida extracts(FUP) against HCT-15 colon cancer cells. Method : By measuring cell proliferation, DNA fragmentation, cell cycle, morphology, and western blot from FUP, the study investigated the effects of the extractions had upon the HCT-15 colon cancer cells, and concluded that the inhibiting effects upon cells were induced by apoptosis. Result : FUP effectively inhibited the growth of HCT-15 colon cancer cells. After analyzing the DNA fragmentation, the study observed a DNA ladder, while examining the cells, and found an increase of sub-G1 hypodiploid cells. On the changes regarding the nucleus of the cells, a condensation of cells and chromatin, as well as an apoptotic body was clearly observed. By observing through western blot from FUP, the study found a decreased level of Bcl-2 from HCT-15 colon cancer cells, but the increased level of Bax and cleaved caspase-3, which as a result induced apoptosis, inhibiting the growth of HCT-15 colon cancer cells. FUP increased the natural death of HCT-15 colon cancer cells by the induction of apoptosis. FUP seemed to have no suppressing effect upon HL-60/MX2 cells. However, compared to the fucoidan, the study was able to clearly observe morphological changes of HCT-15 cells apoptosis, in a 1/2 concentration. Conclusion : FUP had antiproliferative effects on different kinds of cancer cells, while proving especially efficacious against colon cancer cells. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 미역 발효추출물의 HCT-15 대장암 세포 사멸 유도 효과 | - |
dc.title.alternative | Apoptosis Induction of HCT-15 Cells by Extracts of Undaria pinnatifida with Fermented Micro-organism | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.28, no.4, pp.33 - 40 | - |
dc.identifier.kciid | ART001791583 | - |
dc.citation.endPage | 40 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 김태윤 | - |
dc.contributor.affiliatedAuthor | 이영종 | - |
dc.subject.keywordAuthor | fermented Undaria pinnatifida | - |
dc.subject.keywordAuthor | colon cancer cell | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.description.journalRegisteredClass | kci | - |
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