Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities
DC Field | Value | Language |
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dc.contributor.author | Park, Kyoung Jin | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Khan, Zahra | - |
dc.contributor.author | Oh, Joonseok | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-27T03:41:37Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1539 | - |
dc.description.abstract | Seven new Securinega alkaloids, securingines A-G (1-7), together with seven known analogues (8-14), were isolated from the twigs of Securinega suffruticosa. Their chemical structures were elucidated by a combined approach of spectroscopic analysis, chemical methods, ECD calculations, and DP4+ probability analysis. The full NMR assignments and the absolute configuration of compound 8 are also reported. In addition, all the isolated phytochemicals (1-14) were assessed for their cytotoxic, anti-inflammatory, and potential neuroprotective activities. Compound 4 showed cytotoxic activity (IC50 values of 1.5-6.8 mu M) against four human cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 3, 10, 12, and 13 showed potent inhibitory effects on nitric oxide production (IC50 values of 12.6, 12.1, 1.1, and 7.7 mu M, respectively) in lipopolysaccharide-stimulated murine microglia BV-2 cells. Compound 5 exhibited a nerve growth factor production effect (172.6 +/- 1.2%) in C6 glioma cells at 20 mu g/mL. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | GLYCOSIDES | - |
dc.title | Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000469410200035 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00142 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.82, no.5, pp.1345 - 1353 | - |
dc.identifier.scopusid | 2-s2.0-85066137899 | - |
dc.citation.endPage | 1353 | - |
dc.citation.startPage | 1345 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 82 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Khan, Zahra | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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