Environmental pyrethroid exposure and diabetes in US adults
- Authors
- Park, Jeehea; Park, Sung Kyun; Choi, Yoon-Hyeong
- Issue Date
- May-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Pyrethroid; Diabetes; Pesticides; NHANES; Epidemiology
- Citation
- ENVIRONMENTAL RESEARCH, v.172, pp.399 - 407
- Journal Title
- ENVIRONMENTAL RESEARCH
- Volume
- 172
- Start Page
- 399
- End Page
- 407
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1546
- DOI
- 10.1016/j.envres.2018.12.043
- ISSN
- 0013-9351
- Abstract
- Pyrethroid insecticides have been used widely as replacements for organophosphate insecticides over the past decades. While several animal studies suggest that exposure to pyrethroids can alter glucose homeostasis, there is only limited evidence of the association between environmental pyrethroid exposure and diabetes risk in human populations. Therefore, we examined the National Health and Nutrition Examination Survey (NHANES) 2007-2010 data to determine the association between environmental pyrethroid exposure and the prevalence of diabetes in the general U.S. population. Using data on 2796 participants aged 20-79 years from NHANES 2007-2010, we estimated odds ratios (ORs) and 95% confidence intervals (CI) of the association between diabetes and urinary metabolite concentration of pyrethroids using logistic regression. The weighted prevalence of diabetes was 10.3%. The weighted geometric means and detection rate of 3-phenoxybenzoic acid (3-PBA), the most common nonspecific pyrethroid metabolite, were 0.41 mu g/L (95% CI: 0.38, 0.45) and 72.0%, respectively. After adjusting for sociodemographic, behavioral, and metabolic factors, we found a significant dose-response relationship between urinary 3-PBA as quartile and prevalent diabetes (p-trend = 0.007). Compared to the lowest quartile of 3-PBA, the highest quartile had OR of 2.18 (95% CI: 1.18, 4.03) for diabetes. Our finding suggests pyrethroid insecticides as a potential risk factor for diabetes. Further studies should be conducted to confirm our finding and to determine if this association is causal.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1546)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.