熟地養筋湯 추출물이 흰쥐 좌골신경 손상 후에 기능회복과 염증 매개 인자 발현에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장건 | - |
dc.contributor.author | 송윤경 | - |
dc.contributor.author | 임형호 | - |
dc.date.available | 2020-02-29T03:42:09Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1229-1854 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15575 | - |
dc.description.abstract | Objectives :Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficits. Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ), in oriental medicine, has been used to treat various musculoskeletal disorders. Methods :In the present study, the effects of aqueous extract of Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), inducible nitric oxide synthase(iNOS), and tumor necrosis factor-α(TNF-α) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot analysis for COX-2 iNOS, and TNF-α, and Immunofluorescence test for neurofilament were performed. Results :In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2, iNOS and TNF-α expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury, In contrast, treatment with Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) treatment also suppressed COX-2, iNOS, and TNF-α expressions and enhanced the neurofilament expression in sciatic crushed nerve injury. Conclusions :In the present study, we have shown that Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한방재활의학과학회 | - |
dc.relation.isPartOf | 한방재활의학과학회지 | - |
dc.title | 熟地養筋湯 추출물이 흰쥐 좌골신경 손상 후에 기능회복과 염증 매개 인자 발현에 미치는 영향 | - |
dc.title.alternative | Effect of Aqueous Extract of Sukjiyanggeun-Tang(shú dˋl yǎngj l̄n-tāng) on Functional Recovery and Expressions of Inflammatory Mediators after Sciatic Nerve Crushed Injury in Rat | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 한방재활의학과학회지, v.23, no.2, pp.33 - 48 | - |
dc.identifier.kciid | ART001765707 | - |
dc.citation.endPage | 48 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | 한방재활의학과학회지 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 장건 | - |
dc.contributor.affiliatedAuthor | 송윤경 | - |
dc.contributor.affiliatedAuthor | 임형호 | - |
dc.subject.keywordAuthor | Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) | - |
dc.subject.keywordAuthor | Sciatic nerve injury | - |
dc.subject.keywordAuthor | Axonal Regeneration | - |
dc.subject.keywordAuthor | Sciatic functional index | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | TNF-α | - |
dc.description.journalRegisteredClass | kci | - |
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