Inhibitory Effect of Snake Venom Toxin on Colorectal Cancer HCT116 Cells Growth through Induction of Intrinsic or Extrinsic Apoptosis
DC Field | Value | Language |
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dc.contributor.author | 김경태 | - |
dc.contributor.author | 송호섭 | - |
dc.date.available | 2020-02-29T04:42:07Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2586-288X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15849 | - |
dc.description.abstract | I investigated whether snake venom toxin(SVT) from Vipera lebetina turanica enhances the apoptosis ability of tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) in cancer cells. TRAIL inhibited HCT116 cell growth in a dose-dependent manner. Consistent with cell growth inhibition, the expression of TRAIL receptors; DR4 and DR5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, 8, 9 and Bax. However, the expression of survival proteins(eg, cFLIP, survivin, XIAP and Bcl2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the reactive oxygen species(ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the apoptosis related protein such as caspase-3 and-9 as well as cell growth inhibitory effects. The collective results suggest that SVT facilitates TRAIL-induced apoptosis in human colorectal cancer HCT116 cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS pathway signals. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한침구의학회 | - |
dc.relation.isPartOf | Journal of Acupuncture Research | - |
dc.title | Inhibitory Effect of Snake Venom Toxin on Colorectal Cancer HCT116 Cells Growth through Induction of Intrinsic or Extrinsic Apoptosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | Journal of Acupuncture Research, v.30, no.1, pp.43 - 55 | - |
dc.identifier.kciid | ART001742143 | - |
dc.citation.endPage | 55 | - |
dc.citation.startPage | 43 | - |
dc.citation.title | Journal of Acupuncture Research | - |
dc.citation.volume | 30 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 김경태 | - |
dc.contributor.affiliatedAuthor | 송호섭 | - |
dc.subject.keywordAuthor | SVT | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | DR4 | - |
dc.subject.keywordAuthor | DR5 | - |
dc.subject.keywordAuthor | ROS | - |
dc.description.journalRegisteredClass | kci | - |
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