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Cited 34 time in webofscience Cited 36 time in scopus
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Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

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dc.contributor.authorMyung, Nojoon-
dc.contributor.authorConnelly, Stephen-
dc.contributor.authorKim, Boyoung-
dc.contributor.authorPark, Sung Jean-
dc.contributor.authorWilson, Ian A.-
dc.contributor.authorKelly, Jeffery W.-
dc.contributor.authorChoi, Sungwook-
dc.date.available2020-02-29T04:42:25Z-
dc.date.created2020-02-06-
dc.date.issued2013-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15869-
dc.description.abstractWe describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.-
dc.language영어-
dc.language.isoen-
dc.publisherROYAL SOC CHEMISTRY-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.subjectFAMILIAL AMYLOID POLYNEUROPATHY-
dc.subjectPROTEIN-MISFOLDING DISEASES-
dc.subjectSUBSTRUCTURE COMMON-
dc.subjectFIBRIL INHIBITORS-
dc.subjectLIVING CELLS-
dc.subjectLIVE CELLS-
dc.subjectPROBES-
dc.subjectOPTIMIZATION-
dc.subjectENERGETICS-
dc.subjectSTRATEGY-
dc.titleBifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000324490200036-
dc.identifier.doi10.1039/c3cc44667k-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.49, no.80, pp.9188 - 9190-
dc.identifier.scopusid2-s2.0-84884189491-
dc.citation.endPage9190-
dc.citation.startPage9188-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume49-
dc.citation.number80-
dc.contributor.affiliatedAuthorPark, Sung Jean-
dc.type.docTypeArticle-
dc.subject.keywordPlusFAMILIAL AMYLOID POLYNEUROPATHY-
dc.subject.keywordPlusPROTEIN-MISFOLDING DISEASES-
dc.subject.keywordPlusSUBSTRUCTURE COMMON-
dc.subject.keywordPlusFIBRIL INHIBITORS-
dc.subject.keywordPlusLIVING CELLS-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusPROBES-
dc.subject.keywordPlusOPTIMIZATION-
dc.subject.keywordPlusENERGETICS-
dc.subject.keywordPlusSTRATEGY-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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