Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Myung, Nojoon | - |
dc.contributor.author | Connelly, Stephen | - |
dc.contributor.author | Kim, Boyoung | - |
dc.contributor.author | Park, Sung Jean | - |
dc.contributor.author | Wilson, Ian A. | - |
dc.contributor.author | Kelly, Jeffery W. | - |
dc.contributor.author | Choi, Sungwook | - |
dc.date.available | 2020-02-29T04:42:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15869 | - |
dc.description.abstract | We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.subject | FAMILIAL AMYLOID POLYNEUROPATHY | - |
dc.subject | PROTEIN-MISFOLDING DISEASES | - |
dc.subject | SUBSTRUCTURE COMMON | - |
dc.subject | FIBRIL INHIBITORS | - |
dc.subject | LIVING CELLS | - |
dc.subject | LIVE CELLS | - |
dc.subject | PROBES | - |
dc.subject | OPTIMIZATION | - |
dc.subject | ENERGETICS | - |
dc.subject | STRATEGY | - |
dc.title | Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324490200036 | - |
dc.identifier.doi | 10.1039/c3cc44667k | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.49, no.80, pp.9188 - 9190 | - |
dc.identifier.scopusid | 2-s2.0-84884189491 | - |
dc.citation.endPage | 9190 | - |
dc.citation.startPage | 9188 | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 80 | - |
dc.contributor.affiliatedAuthor | Park, Sung Jean | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FAMILIAL AMYLOID POLYNEUROPATHY | - |
dc.subject.keywordPlus | PROTEIN-MISFOLDING DISEASES | - |
dc.subject.keywordPlus | SUBSTRUCTURE COMMON | - |
dc.subject.keywordPlus | FIBRIL INHIBITORS | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | OPTIMIZATION | - |
dc.subject.keywordPlus | ENERGETICS | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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