Prognostic Role of Serum Lactate Dehydrogenase Beyond Initial Diagnosis: A Retrospective Analysis of Patients with Diffuse Large B Cell Lymphoma
DC Field | Value | Language |
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dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Yoon, Hyun-Hwa | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Sym, Sun Jin | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Park, Pil-Whan | - |
dc.contributor.author | Ahn, Jeong Yeal | - |
dc.contributor.author | Park, Sanghui | - |
dc.contributor.author | Cho, Eun Kyung | - |
dc.contributor.author | Shin, Dong Bok | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.date.available | 2020-02-29T04:43:34Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15914 | - |
dc.description.abstract | Background/Aims: Baseline serum lactate dehydrogenase (LDH) level is a well-known prognostic factor in patients with non-Hodgkin's lymphoma; however, its role beyond initial diagnosis has not yet been defined. Methods: This study was conducted as a retrospective analysis of patients with diffuse large B cell lymphoma (DLBCL) treated with R-CHOP21, who had undergone regular checks for LDH during immunochemotherapy (n = 119) and during the posttreatment follow-up period after complete remission (CR; n = 100). The 119 patients were classified into 4 groups according to their baseline and change in LDH level during treatment, and an analysis of tumor response and survival was performed. The value of LDH as a predictor for relapse was evaluated among the patients with regular follow-up visits after achieving CR. Results: An increased LDH level during immunochemotherapy had no impact on tumor response or survival, and only the LDH status 'before' treatment was a prognostic marker. The sensitivity, specificity, positive predictive value and negative predictive value of serum LDH for detecting relapse after CR were 47.4, 86.5, 9.3 and 98.3%, respectively. Conclusion: The measurement of LDH level beyond initial diagnosis has no clear benefit in predicting disease progression or relapse in patients with DLBCL treated with R-CHOP21. Copyright (C) 2013 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.relation.isPartOf | ACTA HAEMATOLOGICA | - |
dc.title | Prognostic Role of Serum Lactate Dehydrogenase Beyond Initial Diagnosis: A Retrospective Analysis of Patients with Diffuse Large B Cell Lymphoma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000327462800015 | - |
dc.identifier.doi | 10.1159/000353127 | - |
dc.identifier.bibliographicCitation | ACTA HAEMATOLOGICA, v.130, no.4, pp.305 - 311 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84888273503 | - |
dc.citation.endPage | 311 | - |
dc.citation.startPage | 305 | - |
dc.citation.title | ACTA HAEMATOLOGICA | - |
dc.citation.volume | 130 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Yoon, Hyun-Hwa | - |
dc.contributor.affiliatedAuthor | Ahn, Hee Kyung | - |
dc.contributor.affiliatedAuthor | Sym, Sun Jin | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.contributor.affiliatedAuthor | Park, Pil-Whan | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong Yeal | - |
dc.contributor.affiliatedAuthor | Cho, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Dong Bok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Lactate dehydrogenase | - |
dc.subject.keywordAuthor | Non-Hodgkin lymphoma | - |
dc.subject.keywordAuthor | Diffuse large B cell lymphoma | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | SURVEILLANCE CT SCANS | - |
dc.subject.keywordPlus | PERIPHERAL T-CELL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | COMPLETE REMISSION | - |
dc.subject.keywordPlus | RITUXIMAB | - |
dc.subject.keywordPlus | CYCLOPHOSPHAMIDE | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | VINCRISTINE | - |
dc.subject.keywordPlus | LYMPHOPENIA | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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