Detailed Information

Cited 19 time in webofscience Cited 18 time in scopus
Metadata Downloads

Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: Implications on signal transducer and activator of transcription-1 signaling and nitric oxide production

Full metadata record
DC Field Value Language
dc.contributor.authorPark, Ki Hwan-
dc.contributor.authorYoon, Yeo Dae-
dc.contributor.authorHan, Sang-Bae-
dc.contributor.authorOh, Soo Jin-
dc.contributor.authorYun, Jieun-
dc.contributor.authorLee, Chang Woo-
dc.contributor.authorLee, Kiho-
dc.contributor.authorPark, Song-Kyu-
dc.contributor.authorKim, Hwan Mook-
dc.contributor.authorKang, Jong Soon-
dc.date.available2020-02-29T04:44:19Z-
dc.date.created2020-02-06-
dc.date.issued2012-12-
dc.identifier.issn1567-5769-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15948-
dc.description.abstractArtemisinin is a well-known anti-malarial drug and has been shown to inhibit nitric oxide (NO) production. In this study, we investigated the effect of artemisinin on lipopolysaccharide (LPS)-induced production of IFN-beta and characterized the potential relationship between artemisinin-mediated inhibition of IFN-beta and NO production. Artemisinin suppressed IFN-beta production and mRNA expression in a dose-dependent manner in LPS-stimulated RAW 264.7 cells. LPS-induced phosphorylation of signal transducer and activator of transcription-1 (STAT-1) was also inhibited by artemisinin treatment in RAW 264.7 cells. In addition, artemisinin suppressed LPS-induced production of NO in RAW 264.7 cells. Further study demonstrated that artemisinin-mediated inhibition of NO production and STAT-1 phosphorylation was reversed by addition of exogenous IFN-beta. Moreover, artemisinin does not affect IFN-beta-induced STAT-1 phosphorylation in RAW 264.7 cells. Collectively, these results suggest that the inhibition of IFN-beta production by artemisinin and concomitant attenuation of STAT-1 activation might be involved in artemisinin-mediated inhibition of NO production in macrophages. (c) 2012 Elsevier B.V. All rights reserved.-
dc.language영어-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.isPartOfINTERNATIONAL IMMUNOPHARMACOLOGY-
dc.subjectNF-KAPPA-B-
dc.subjectMACROPHAGES-
dc.subjectSYNTHASE-
dc.subjectEXPRESSION-
dc.subjectINDUCTION-
dc.subjectDERIVATIVES-
dc.subjectGENE-
dc.subjectSELF-
dc.titleArtemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: Implications on signal transducer and activator of transcription-1 signaling and nitric oxide production-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000313152900030-
dc.identifier.doi10.1016/j.intimp.2012.09.012-
dc.identifier.bibliographicCitationINTERNATIONAL IMMUNOPHARMACOLOGY, v.14, no.4, pp.580 - 584-
dc.identifier.scopusid2-s2.0-84867607963-
dc.citation.endPage584-
dc.citation.startPage580-
dc.citation.titleINTERNATIONAL IMMUNOPHARMACOLOGY-
dc.citation.volume14-
dc.citation.number4-
dc.contributor.affiliatedAuthorKim, Hwan Mook-
dc.type.docTypeArticle-
dc.subject.keywordAuthorArtemisinin-
dc.subject.keywordAuthorIFN-beta-
dc.subject.keywordAuthorSTAT-1-
dc.subject.keywordAuthorNitric oxide-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusSYNTHASE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusSELF-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Hwan Mook photo

Kim, Hwan Mook
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE