Dutasteride, who is it more effective for? Second to fourth digit ratio and the relationship with prostate volume reduction by dutasteride treatment
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Beom | - |
dc.contributor.author | Oh, Jin Kyu | - |
dc.contributor.author | Kim, Khae Hawn | - |
dc.contributor.author | Jung, Han | - |
dc.contributor.author | Yoon, Sang Jin | - |
dc.contributor.author | Lee, Min Sung | - |
dc.contributor.author | Kim, Soo Woong | - |
dc.date.available | 2020-02-29T04:44:26Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1464-4096 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15955 | - |
dc.description.abstract | OBJECTIVE To investigate the relationship between second to fourth digit ratio (hereafter the digit ratio) and prostate volume reduction by dutasteride treatment. PATIENTS AND METHODS A total of 142 men aged >= 40 years with a clinical diagnosis of benign prostatic hyperplasia and an enlarged prostate (prostate volume >= 30 mL) were prospectively enrolled. Before prostate-specific antigen (PSA) level determination and transrectal ultrasonography (TRUS), the lengths of the second and fourth digits of the right hand were measured by an investigator using a digital vernier calliper. Using TRUS, pre- and post-treatment prostate volume (PV1 and PV2) were measured by an uroradiologist who was unaware of finger lengths. We investigated the change in prostate volume and PSA level at least 6 months after the initiation of dutasteride therapy. RESULTS When the patients were divided into two groups according to digit ratio (A: digit ratio <0.95, n = 71; B: digit ratio >= 0.95, n = 71), there was a greater reduction in prostate volume in group B compared to group A (PV2 -PV1: -9.4 mL vs -13.2 mL, P = 0.042; [PV2 -PV1]/PV1: -17.5% vs -24.5%, P = 0.027; [PV2 -PV1]/duration: -1.1 mL/month vs-1.6 mL/month, P = 0.041; [PV2-PV1]/PV1/duration: -2.0%/month vs-3.0%/month, P = 0.016). Significant negative correlations were found between the digit ratio and reduction rate ([PV2 -PV1] /duration: r = -0.165, P = 0.049; [PV2 -PV1] /PV1/duration: r = -0.191, P = 0.023). CONCLUSIONS Patients with higher digit ratios respond well to dutasteride treatment. The results obtained in the present study suggest that the digit ratio is a predictor of the response to dutasteride treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | BJU INTERNATIONAL | - |
dc.title | Dutasteride, who is it more effective for? Second to fourth digit ratio and the relationship with prostate volume reduction by dutasteride treatment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000315029700011 | - |
dc.identifier.doi | 10.1111/j.1464-410X.2012.11343.x | - |
dc.identifier.bibliographicCitation | BJU INTERNATIONAL, v.110, no.11C, pp.E857 - E863 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85027953056 | - |
dc.citation.endPage | E863 | - |
dc.citation.startPage | E857 | - |
dc.citation.title | BJU INTERNATIONAL | - |
dc.citation.volume | 110 | - |
dc.citation.number | 11C | - |
dc.contributor.affiliatedAuthor | Kim, Tae Beom | - |
dc.contributor.affiliatedAuthor | Oh, Jin Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Khae Hawn | - |
dc.contributor.affiliatedAuthor | Jung, Han | - |
dc.contributor.affiliatedAuthor | Yoon, Sang Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | benign prostatic hyperplasia | - |
dc.subject.keywordAuthor | digit ratio dutasteride | - |
dc.subject.keywordAuthor | prostate volume | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR GENE | - |
dc.subject.keywordPlus | DUAL 5-ALPHA-REDUCTASE INHIBITOR | - |
dc.subject.keywordPlus | CAG REPEAT | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | FINASTERIDE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TESTOSTERONE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | LENGTH | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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