Electrochemical DNA detection using Hoechst dyes in microfluidic chips
- Authors
- Zhao, Haiming; Li, Zhiqiang; Lee, Nae Yoon; Kim, Jong Sung; Lee, Eun-Cheol
- Issue Date
- Nov-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- DNA sensor; Hoechst; Microfluidic chip; Immobilization-free process; Regeneration
- Citation
- CURRENT APPLIED PHYSICS, v.12, no.6, pp.1493 - 1496
- Journal Title
- CURRENT APPLIED PHYSICS
- Volume
- 12
- Number
- 6
- Start Page
- 1493
- End Page
- 1496
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16026
- DOI
- 10.1016/j.cap.2012.04.023
- ISSN
- 1567-1739
- Abstract
- We fabricate microfluidic DNA sensors based on the electrochemical method that uses Hoechst 33258 [2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi(1H-benzimidazole)] as a DNA intercalator. These chips are fabricated without a probe immobilization process, thereby being more simply regenerated than other typical DNA chips. Linear sweep voltammetric measurements show an anodic-current decrease consistent with the DNA duplex formation which occurs when the target is fully complementary to the probe, enabling sequence-specific DNA detection. (C) 2012 Elsevier B.V. All rights reserved.
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Collections - 바이오나노대학 > 나노물리학과 > 1. Journal Articles
- 공과대학 > 화공생명공학과 > 1. Journal Articles
- 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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