Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mi Young | - |
dc.contributor.author | Choi, Ran | - |
dc.contributor.author | Kim, Hong Min | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Kim, Bo Hwan | - |
dc.contributor.author | Choi, Yeon Sik | - |
dc.contributor.author | Naowaboot, Jarinyaporn | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Yang, Young Chul | - |
dc.contributor.author | Shin, Jang Ye | - |
dc.contributor.author | Shin, Young Goo | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.date.available | 2020-02-29T04:47:31Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16071 | - |
dc.description.abstract | Although peroxisome proliferator receptor (PPAR)-alpha and PPAR-gamma agonist have been developed as chemical tools to uncover biological roles for the PPARs such as lipid and carbohydrate metabolism, PPAR-delta has not been fully investigated. In this study, we examined the effects of the PPAR-delta agonist GW0742 on fatty liver changes and inflammatory markers. We investigated the effects of PPAR-delta agonist GW0742 on fatty liver changes in OLETF rats. Intrahepatic triglyceride contents and expression of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and monocyte chemo-attractant protein-1 (MCP-1) and also, PPAR-gamma coactivator (PGC)-1 alpha gene were evaluated in liver tissues of OLETF rats and HepG2 cells after GW0742 treatment. The level of TNF-alpha and MCP-1 was also examined in supernatant of Raw264. 7 cell culture. To address the effects of GW0742 on insulin signaling, we performed in vitro study with AML12 mouse hepatocytes. Rats treated with GW0742 (10 mg/kg/day) from 26 to 36 weeks showed improvement in fatty infiltration of the liver. In liver tissues, mRNA expressions of TNF-alpha, MCP-1, and PGC-1 alpha were significantly decreased in diabetic rats treated with GW0742 compared to diabetic control rats. We also observed that GW0742 had inhibitory effects on palmitic acid-induced fatty accumulation and inflammatory markers in HepG2 and Ravv264.7 cells. The expression level of Akt and IRS-1 was significantly increased by treatment with GW0742. The PPAR-delta agonist may attenuate hepatic fat accumulation through anti-inflammatory mechanism, reducing hepatic PGC-1 alpha gene expression, and improvement of insulin signaling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | MUSCLE-CELLS | - |
dc.subject | PPAR-DELTA | - |
dc.subject | LIVER | - |
dc.subject | INFLAMMATION | - |
dc.subject | EXPRESSION | - |
dc.subject | STEATOHEPATITIS | - |
dc.subject | PGC-1-ALPHA | - |
dc.subject | ADIPOCYTES | - |
dc.title | Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000310770700002 | - |
dc.identifier.doi | 10.3858/emm.2012.44.10.066 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.44, no.10, pp.578 - 585 | - |
dc.identifier.kciid | ART001705687 | - |
dc.identifier.scopusid | 2-s2.0-84868132548 | - |
dc.citation.endPage | 585 | - |
dc.citation.startPage | 578 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 44 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Bo Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | fatty liver | - |
dc.subject.keywordAuthor | GW0742 | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | monocyte chemo-attractant protein-1 | - |
dc.subject.keywordAuthor | PPAR delta | - |
dc.subject.keywordAuthor | PPARGC1A protein, human | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | MUSCLE-CELLS | - |
dc.subject.keywordPlus | PPAR-DELTA | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STEATOHEPATITIS | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
dc.subject.keywordPlus | ADIPOCYTES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.