Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Se Jin | - |
dc.contributor.author | Han, Seol-Heui | - |
dc.contributor.author | Yang, Sung-Il | - |
dc.contributor.author | Choi, Ji Woong | - |
dc.contributor.author | Kwon, Kyoung Ja | - |
dc.contributor.author | Park, Seung Hwa | - |
dc.contributor.author | Kim, Hahn Young | - |
dc.contributor.author | Cheong, Jae Hoon | - |
dc.contributor.author | Ryu, Jong Hoon | - |
dc.contributor.author | Ko, Kwang Ho | - |
dc.contributor.author | Wells, David G. | - |
dc.contributor.author | Shin, Chan Young | - |
dc.date.available | 2020-02-29T04:48:00Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16095 | - |
dc.description.abstract | J. Neurochem. (2012) 123, 226238. Abstract Fragile X syndrome (FXS), the most common single genetic cause of mental retardation and autistic spectrum disease, occurs when FMR1 gene is mutated. FMR1 encodes fragile X mental retardation protein (FMRP) which regulates translation of mRNAs playing important roles in the development of neurons as well as formation and maintenance of synapses. To examine whether FMRP regulates cell viability, we induced apoptosis in rat primary cortical neurons with glutamate in vitro and with middle cerebral artery occlusion (MCAO) in striatal neurons in vivo. Both conditions elicited a rapid, but transient FMRP expression in neurons. This up-regulated FMRP expression was abolished by pre-treatment with PI3K and Protein Kinase B (Akt) inhibitors: LY294002, Akt inhibitor IV, and VIII. Reduced FMRP expression in vitro or in vivo using small hairpin Fmr1 virus exacerbated cell death by glutamate or MCAO, presumably via hypophosphorylation of Akt and reduced expression of B-cell lymphoma-extra large (Bcl-xL). However, over-expression of FMRP using enhanced green fluorescent protein (eGFP)-FMRP constructs alleviated cell death, increased Akt activity, and enhanced Bcl-xL production. The pro-survival role of Akt-dependent up-regulation of FMRP in glutamate-stimulated cultured neuron as well as in ischemic brain may have a clinical importance in FXS as well as in neurodegenerative disorders and traumatic brain injury. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | JOURNAL OF NEUROCHEMISTRY | - |
dc.subject | MENTAL-RETARDATION PROTEIN | - |
dc.subject | FRAGILE-X-SYNDROME | - |
dc.subject | LONG-TERM DEPRESSION | - |
dc.subject | RNA-BINDING-PROTEIN | - |
dc.subject | NEURAL STEM-CELLS | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | TARGET | - |
dc.subject | SURVIVAL | - |
dc.subject | GENE | - |
dc.title | Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309454300003 | - |
dc.identifier.doi | 10.1111/j.1471-4159.2012.07886.x | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.123, no.2, pp.226 - 238 | - |
dc.identifier.scopusid | 2-s2.0-84867067796 | - |
dc.citation.endPage | 238 | - |
dc.citation.startPage | 226 | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 123 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Choi, Ji Woong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | Bcl-xL | - |
dc.subject.keywordAuthor | FMRP | - |
dc.subject.keywordAuthor | glutamate | - |
dc.subject.keywordAuthor | ischemia | - |
dc.subject.keywordAuthor | neuronal survival | - |
dc.subject.keywordPlus | MENTAL-RETARDATION PROTEIN | - |
dc.subject.keywordPlus | FRAGILE-X-SYNDROME | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | RNA-BINDING-PROTEIN | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GENE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.