Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Kyung-Won | - |
dc.contributor.author | Ko, Kwang-Pil | - |
dc.contributor.author | Ahn, Younjhin | - |
dc.contributor.author | Kim, Cheong-Sik | - |
dc.contributor.author | Park, Seon-Joo | - |
dc.contributor.author | Park, Jae Kyung | - |
dc.contributor.author | Kim, Sung Soo | - |
dc.contributor.author | Kim, Yeonjung | - |
dc.date.available | 2020-02-29T04:48:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1865-3499 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16119 | - |
dc.description.abstract | Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equol production on health in Koreans and identified the genetic factors that determine the equol-producing phenotype. In 1391 subjects, the equol-producing phenotype was determined, based on measurements of serum equol concentrations. The anthropometric and blood biochemical measurements between equol producers and nonproducers were analyzed by LC-MS/MS. Genetic factors were identified in a genomewide association study (GWAS), and the interaction between genetic factors and the equol-producing phenotype was examined. We observed that 70.1 % of the study population produced equol. Blood pressure was significantly lower in equol producers (beta +/- A SE = -1.35 +/- A 0.67, p = 0.045). In our genomewide association study, we identified 5 single-nucleotide polymorphisms (p < 1 x 10(-5)) in HACE1. The most significant SNP was rs6927608, and individuals with a minor allele of rs6927608 did not produce equol (odds ratio = 0.57 (95 % CI 0.45-0.72), p value = 2.5 x 10(-6)). Notably, the interaction between equol production and the rs6927608 HACE1 SNP was significantly associated with systolic blood pressure (p value = 1.3 x 10(4)). Equol production is linked to blood pressure, and HACE1, identified in our (GWAS), might be a determinant of the equol-producing phenotype. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.isPartOf | GENES AND NUTRITION | - |
dc.subject | ESTROGEN-RECEPTOR BINDING | - |
dc.subject | BONE-MINERAL DENSITY | - |
dc.subject | WIDE ASSOCIATION | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | HUMAN HEALTH | - |
dc.subject | POSTMENOPAUSAL WOMEN | - |
dc.subject | SOY ISOFLAVONES | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | WILMS-TUMOR | - |
dc.subject | PHYTOESTROGENS | - |
dc.title | Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309078700010 | - |
dc.identifier.doi | 10.1007/s12263-012-0292-8 | - |
dc.identifier.bibliographicCitation | GENES AND NUTRITION, v.7, no.4, pp.567 - 574 | - |
dc.identifier.scopusid | 2-s2.0-84872191509 | - |
dc.citation.endPage | 574 | - |
dc.citation.startPage | 567 | - |
dc.citation.title | GENES AND NUTRITION | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Ko, Kwang-Pil | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Equol | - |
dc.subject.keywordAuthor | Isoflavone | - |
dc.subject.keywordAuthor | HACE1 | - |
dc.subject.keywordAuthor | Korean | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR BINDING | - |
dc.subject.keywordPlus | BONE-MINERAL DENSITY | - |
dc.subject.keywordPlus | WIDE ASSOCIATION | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | HUMAN HEALTH | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | SOY ISOFLAVONES | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | WILMS-TUMOR | - |
dc.subject.keywordPlus | PHYTOESTROGENS | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.