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The Effect of Renin-Angiotensin-Aldosterone System Blockade on Contrast-Induced Acute Kidney Injury: A Propensity-Matched Study

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dc.contributor.authorRim, Min Young-
dc.contributor.authorRo, Han-
dc.contributor.authorKang, Woong Chol-
dc.contributor.authorKim, Ae Jin-
dc.contributor.authorPark, Hyeonsu-
dc.contributor.authorChang, Jae Hyun-
dc.contributor.authorLee, Hyun Hee-
dc.contributor.authorChung, Wookyung-
dc.contributor.authorJung, Ji Yong-
dc.date.available2020-02-29T04:48:38Z-
dc.date.created2020-02-06-
dc.date.issued2012-10-
dc.identifier.issn0272-6386-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16120-
dc.description.abstractBackground: The role of the angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) in the pathophysiology of contrast-induced acute kidney injury (AKI) is controversial, and the available literature is contradictory. Study Design: A retrospective propensity score-matched study to analyze the effect of ACE-inhibitor/ARB therapy on the development of contrast-induced AKI. Setting & Participants: Using propensity score matching, 1,322 ACE-inhibitor/ARB recipients and nonrecipients were paired for analysis from 5,299 patients and fulfilled the inclusion criteria among 11,447 patients receiving coronary angiography (CAG) or percutaneous coronary intervention. Predictors: ACE-inhibitor/ARB use based on prescription and risk factors for contrast-induced AKI. Outcomes: The incidence of contrast-induced AKI defined by AKI Network (AKIN) criteria: an absolute increase in serum creatinine levels >= 0.3 mg/dL or a relative increase >= 50% from baseline values within 48 hours after exposure to the contrast medium. Measurements: Baseline serum creatinine, hemoglobin, and albumin levels; volume of contrast agents; preprocedural medication; and post-CAG serum creatinine levels. Results: An ACE inhibitor/ARB was prescribed for 64.0% of patients receiving CAG. ACE-inhibitor/ARB users showed an increased incidence of contrast-induced AKI after propensity score matching (11.4% vs 6.3%; P < 0.001). In multivariable analysis, use of ACE inhibitors/ARBs remained an independent and significant predictor of contrast-induced AKI in an unmatched cohort (OR, 1.39; 95% CI, 1.10-1.76; P = 0.06). In the matched cohort, use of ACE inhibitors/ARBs also was associated with a higher adjusted OR of contrast-induced AKI (OR, 1.43; 95% CI, 1.06-1.94; P = 0.02). Limitations: A retrospective study at a single center. Conclusions: Use of ACE inhibitors/ARBs during CAG has a possible influence to increase the incidence of contrast-induced AKI. Further randomized clinical trials are warranted to confirm the effect of ACE-inhibitor/ARB therapy on the development of contrast-induced AKI. Am J Kidney Dis. 60(4):576-582. (C) 2012 by the National Kidney Foundation, Inc.-
dc.language영어-
dc.language.isoen-
dc.publisherW B SAUNDERS CO-ELSEVIER INC-
dc.relation.isPartOfAMERICAN JOURNAL OF KIDNEY DISEASES-
dc.subjectCONVERTING ENZYME-INHIBITORS-
dc.subjectACUTE-RENAL-FAILURE-
dc.subjectINDUCED NEPHROPATHY-
dc.subjectCORONARY INTERVENTION-
dc.subjectANGIOGRAPHY-
dc.subjectPREVENTION-
dc.subjectBLOCKERS-
dc.subjectDISEASE-
dc.titleThe Effect of Renin-Angiotensin-Aldosterone System Blockade on Contrast-Induced Acute Kidney Injury: A Propensity-Matched Study-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000309109400015-
dc.identifier.doi10.1053/j.ajkd.2012.04.017-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF KIDNEY DISEASES, v.60, no.4, pp.576 - 582-
dc.identifier.scopusid2-s2.0-84866354361-
dc.citation.endPage582-
dc.citation.startPage576-
dc.citation.titleAMERICAN JOURNAL OF KIDNEY DISEASES-
dc.citation.volume60-
dc.citation.number4-
dc.contributor.affiliatedAuthorRim, Min Young-
dc.contributor.affiliatedAuthorRo, Han-
dc.contributor.affiliatedAuthorKang, Woong Chol-
dc.contributor.affiliatedAuthorKim, Ae Jin-
dc.contributor.affiliatedAuthorPark, Hyeonsu-
dc.contributor.affiliatedAuthorChang, Jae Hyun-
dc.contributor.affiliatedAuthorLee, Hyun Hee-
dc.contributor.affiliatedAuthorChung, Wookyung-
dc.contributor.affiliatedAuthorJung, Ji Yong-
dc.type.docTypeArticle-
dc.subject.keywordAuthorContrast-induced acute kidney injury (AKI)-
dc.subject.keywordAuthorangiotensin-converting enzyme ( ACE) inhibitor/angiotensin receptor blocker (ARB)-
dc.subject.keywordAuthorcoronary angiography.-
dc.subject.keywordPlusCONVERTING ENZYME-INHIBITORS-
dc.subject.keywordPlusACUTE-RENAL-FAILURE-
dc.subject.keywordPlusINDUCED NEPHROPATHY-
dc.subject.keywordPlusCORONARY INTERVENTION-
dc.subject.keywordPlusANGIOGRAPHY-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordPlusBLOCKERS-
dc.subject.keywordPlusDISEASE-
dc.relation.journalResearchAreaUrology & Nephrology-
dc.relation.journalWebOfScienceCategoryUrology & Nephrology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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