The Effect of Renin-Angiotensin-Aldosterone System Blockade on Contrast-Induced Acute Kidney Injury: A Propensity-Matched Study
DC Field | Value | Language |
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dc.contributor.author | Rim, Min Young | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Kang, Woong Chol | - |
dc.contributor.author | Kim, Ae Jin | - |
dc.contributor.author | Park, Hyeonsu | - |
dc.contributor.author | Chang, Jae Hyun | - |
dc.contributor.author | Lee, Hyun Hee | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Jung, Ji Yong | - |
dc.date.available | 2020-02-29T04:48:38Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0272-6386 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16120 | - |
dc.description.abstract | Background: The role of the angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) in the pathophysiology of contrast-induced acute kidney injury (AKI) is controversial, and the available literature is contradictory. Study Design: A retrospective propensity score-matched study to analyze the effect of ACE-inhibitor/ARB therapy on the development of contrast-induced AKI. Setting & Participants: Using propensity score matching, 1,322 ACE-inhibitor/ARB recipients and nonrecipients were paired for analysis from 5,299 patients and fulfilled the inclusion criteria among 11,447 patients receiving coronary angiography (CAG) or percutaneous coronary intervention. Predictors: ACE-inhibitor/ARB use based on prescription and risk factors for contrast-induced AKI. Outcomes: The incidence of contrast-induced AKI defined by AKI Network (AKIN) criteria: an absolute increase in serum creatinine levels >= 0.3 mg/dL or a relative increase >= 50% from baseline values within 48 hours after exposure to the contrast medium. Measurements: Baseline serum creatinine, hemoglobin, and albumin levels; volume of contrast agents; preprocedural medication; and post-CAG serum creatinine levels. Results: An ACE inhibitor/ARB was prescribed for 64.0% of patients receiving CAG. ACE-inhibitor/ARB users showed an increased incidence of contrast-induced AKI after propensity score matching (11.4% vs 6.3%; P < 0.001). In multivariable analysis, use of ACE inhibitors/ARBs remained an independent and significant predictor of contrast-induced AKI in an unmatched cohort (OR, 1.39; 95% CI, 1.10-1.76; P = 0.06). In the matched cohort, use of ACE inhibitors/ARBs also was associated with a higher adjusted OR of contrast-induced AKI (OR, 1.43; 95% CI, 1.06-1.94; P = 0.02). Limitations: A retrospective study at a single center. Conclusions: Use of ACE inhibitors/ARBs during CAG has a possible influence to increase the incidence of contrast-induced AKI. Further randomized clinical trials are warranted to confirm the effect of ACE-inhibitor/ARB therapy on the development of contrast-induced AKI. Am J Kidney Dis. 60(4):576-582. (C) 2012 by the National Kidney Foundation, Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF KIDNEY DISEASES | - |
dc.subject | CONVERTING ENZYME-INHIBITORS | - |
dc.subject | ACUTE-RENAL-FAILURE | - |
dc.subject | INDUCED NEPHROPATHY | - |
dc.subject | CORONARY INTERVENTION | - |
dc.subject | ANGIOGRAPHY | - |
dc.subject | PREVENTION | - |
dc.subject | BLOCKERS | - |
dc.subject | DISEASE | - |
dc.title | The Effect of Renin-Angiotensin-Aldosterone System Blockade on Contrast-Induced Acute Kidney Injury: A Propensity-Matched Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309109400015 | - |
dc.identifier.doi | 10.1053/j.ajkd.2012.04.017 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF KIDNEY DISEASES, v.60, no.4, pp.576 - 582 | - |
dc.identifier.scopusid | 2-s2.0-84866354361 | - |
dc.citation.endPage | 582 | - |
dc.citation.startPage | 576 | - |
dc.citation.title | AMERICAN JOURNAL OF KIDNEY DISEASES | - |
dc.citation.volume | 60 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Rim, Min Young | - |
dc.contributor.affiliatedAuthor | Ro, Han | - |
dc.contributor.affiliatedAuthor | Kang, Woong Chol | - |
dc.contributor.affiliatedAuthor | Kim, Ae Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyeonsu | - |
dc.contributor.affiliatedAuthor | Chang, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Hee | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.contributor.affiliatedAuthor | Jung, Ji Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Contrast-induced acute kidney injury (AKI) | - |
dc.subject.keywordAuthor | angiotensin-converting enzyme ( ACE) inhibitor/angiotensin receptor blocker (ARB) | - |
dc.subject.keywordAuthor | coronary angiography. | - |
dc.subject.keywordPlus | CONVERTING ENZYME-INHIBITORS | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | INDUCED NEPHROPATHY | - |
dc.subject.keywordPlus | CORONARY INTERVENTION | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | BLOCKERS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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