Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huang, Hu | - |
dc.contributor.author | Kong, Dong | - |
dc.contributor.author | Byun, Kyung Hee | - |
dc.contributor.author | Ye, Chianping | - |
dc.contributor.author | Koda, Shuichi | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Oh, Byung-Chul | - |
dc.contributor.author | Lee, Sam W. | - |
dc.contributor.author | Lee, Bonghee | - |
dc.contributor.author | Zabolotny, Janice M. | - |
dc.contributor.author | Kim, Min Seon | - |
dc.contributor.author | Bjorbaek, Christian | - |
dc.contributor.author | Lowell, Bradford B. | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.date.available | 2020-02-29T04:48:42Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16121 | - |
dc.description.abstract | Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical interaction of JAK2 and ROCK1, thereby increasing phosphorylation of JAK2 and downstream activation of Stat3 and FOXO1. Mice lacking ROCK1 in either pro-opiomelanocortin (POMC) or agouti-related protein neurons, mediators of leptin action, displayed obesity and impaired leptin sensitivity. In addition, deletion of ROCK1 in the arcuate nucleus markedly enhanced food intake, resulting in severe obesity. Notably, ROCK1 was a specific mediator of leptin, but not insulin, regulation of POMC neuronal activity. Our data identify ROCK1 as a key regulator of leptin action on energy homeostasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE NEUROSCIENCE | - |
dc.subject | PROOPIOMELANOCORTIN MESSENGER-RNA | - |
dc.subject | BODY-WEIGHT | - |
dc.subject | POMC NEURONS | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | ARCUATE NUCLEUS | - |
dc.subject | GLUCOSE-HOMEOSTASIS | - |
dc.subject | IN-VIVO | - |
dc.subject | INSULIN | - |
dc.subject | MICE | - |
dc.subject | ROCK1 | - |
dc.title | Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309335300019 | - |
dc.identifier.doi | 10.1038/nn.3207 | - |
dc.identifier.bibliographicCitation | NATURE NEUROSCIENCE, v.15, no.10, pp.1391 - 1398 | - |
dc.identifier.scopusid | 2-s2.0-84866735424 | - |
dc.citation.endPage | 1398 | - |
dc.citation.startPage | 1391 | - |
dc.citation.title | NATURE NEUROSCIENCE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Byun, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Oh, Byung-Chul | - |
dc.contributor.affiliatedAuthor | Lee, Bonghee | - |
dc.contributor.affiliatedAuthor | Kim, Young-Bum | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROOPIOMELANOCORTIN MESSENGER-RNA | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | POMC NEURONS | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | ARCUATE NUCLEUS | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ROCK1 | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.