Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Eunhui | - |
dc.contributor.author | Kang, Hwansu | - |
dc.contributor.author | Choi, Hojung | - |
dc.contributor.author | Choi, Woohyuk | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-02-27T03:42:12Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1612 | - |
dc.description.abstract | Aging is a major risk factor for many chronic diseases due to increased vulnerability to external stress and susceptibility to disease. Aging is associated with metabolic liver disease such as nonalcoholic fatty liver. In this study, we investigated changes in lipid metabolism during aging in mice and the mechanisms involved. Lipid accumulation was increased in liver tissues of aged mice, particularly cholesterol. Increased uptake of both cholesterol and glucose was observed in hepatocytes of aged mice as compared with younger mice. The mRNA expression of GLUT2, GK, SREBP2, HMGCR, and HMGCS, genes for cholesterol synthesis, was gradually increased in liver tissues during aging. Reactive oxygen species (ROS) increase with aging and are closely related to various aging-related diseases. When we treated HepG2 cells and primary hepatocytes with the ROS inducer, H2O2, lipid accumulation increased significantly compared to the case for untreated HepG2 cells. H2O2 treatment significantly increased glucose uptake and acetyl-CoA production, which results in glycolysis and lipid synthesis. Treatment with H2O2 significantly increased the expression of mRNA for genes related to cholesterol synthesis and uptake. These results suggest that ROS play an important role in altering cholesterol metabolism and consequently contribute to the accumulation of cholesterol in the liver during the aging process. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | AGING CELL | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | HEPATIC STEATOSIS | - |
dc.subject | DISEASE | - |
dc.subject | PREVALENCE | - |
dc.subject | GENES | - |
dc.title | Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000460963500003 | - |
dc.identifier.doi | 10.1111/acel.12895 | - |
dc.identifier.bibliographicCitation | AGING CELL, v.18, no.2 | - |
dc.identifier.scopusid | 2-s2.0-85059524168 | - |
dc.citation.title | AGING CELL | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Seo, Eunhui | - |
dc.contributor.affiliatedAuthor | Kang, Hwansu | - |
dc.contributor.affiliatedAuthor | Choi, Hojung | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | cholesterol | - |
dc.subject.keywordAuthor | lipid metabolism | - |
dc.subject.keywordAuthor | liver | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | GENES | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.