Lower Salinomycin Concentration Increases Apoptotic Detachment in High-Density Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Ju-Hwa | - |
dc.contributor.author | Kim, Tae Young | - |
dc.contributor.author | Kim, Hyung Sik | - |
dc.contributor.author | Hong, Suntaek | - |
dc.contributor.author | Yoon, Sungpil | - |
dc.date.available | 2020-02-29T05:42:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16137 | - |
dc.description.abstract | The present study identified a novel salinomycin (Sal) sensitization mechanism in cancer. We tested whether Sal reduced proliferation in a high-density population by counting attached cell numbers after Sal treatment. Sal reduced proliferation in high-density cell populations. Longer exposure to Sal further reduced proliferation. Sal concentrations of 0.1 and 5 mu M had similar sensitization effects, suggesting that Sal toxicity was minimal with longer exposure to a high-density cell population. The results suggest that Sal can be applied at a relatively low concentration for a longer time to overcome drug-resistant solid tumors. The 0.5 mu M Sal treatment resulted in fewer attached cells than that of the 5 mu M Sal treatment with a longer exposure. The lower Sal concentration mainly increased the number of easily detachable cells on the surface. In particular, 0.5 mu M Sal increased cellular detachment of newly produced daughter cells. The easily-detachable cells were undergoing apoptosis. It seems that the 0.5 mu M Sal treatment also increased cellular toxicity. These novel findings may contribute to the development of Sal-based therapy for patients with drug-resistant cancer or a high-density solid tumor. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | STEM-CELL | - |
dc.subject | DOXORUBICIN | - |
dc.subject | RESISTANCE | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITOR | - |
dc.subject | PATHWAY | - |
dc.subject | GROWTH | - |
dc.subject | DAMAGE | - |
dc.subject | DRUGS | - |
dc.title | Lower Salinomycin Concentration Increases Apoptotic Detachment in High-Density Cancer Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000310677800057 | - |
dc.identifier.doi | 10.3390/ijms131013169 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.13, no.10, pp.13169 - 13182 | - |
dc.identifier.scopusid | 2-s2.0-84867775843 | - |
dc.citation.endPage | 13182 | - |
dc.citation.startPage | 13169 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 13 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Ju-Hwa | - |
dc.contributor.affiliatedAuthor | Hong, Suntaek | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | salinomycin | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | high cell density | - |
dc.subject.keywordAuthor | spaces among cells | - |
dc.subject.keywordAuthor | cellular detachment | - |
dc.subject.keywordAuthor | lower concentration | - |
dc.subject.keywordPlus | STEM-CELL | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | DRUGS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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