Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-29T05:42:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16138 | - |
dc.description.abstract | In the recent decade, numerous lignan derivatives isolated from plants have been proven to have the potential as an anti-cancer substance. On the search for anti-cancer compounds from Korean medicinal plants, the methanolic extract from the trunk of Tilia amurensis Rupr. (Tiliaceae) was found to have significant cytotoxicity against A549 (lung carcinoma), SK-OV-3 (ovary malignant ascites), SK-MEL-2 (skin melanoma), and HCT-15 (colon adenocarcinoma) in our screening test. Hence, a bioassay-guided fractionation and chemical investigation of the methanolic extract resulted in the isolation and identification of 10 lignan derivatives (1-10) including two new lignan glycosides named tiliamurosides A (1) and B (2). The structures of these new compounds were determined by spectroscopic methods, namely 1D and 2D nuclear magnetic resonance (NMR) techniques, high resolution mass spectrometry (FIRMS), circular dichroism (CD) data, and chemical methods. Tiliamuroside B (2) and schizandriside (3) showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with inhibitory concentration (IC50) values of 3.26-8.89 mu M. Moreover, (-)-syringaresinol (8) and (-)-pinoresinol 4-O-beta-D-glucopyranoside (10) significantly inhibited nitric oxide (NO) production in murine microglia BV-2 with IC50 values of 15.05 and 34.35 mu M, respectively. (c) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.subject | INDONESIAN MEDICINAL-PLANTS | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | SCHISANDRA-CHINENSIS | - |
dc.subject | NEOLIGNAN GLYCOSIDES | - |
dc.subject | PHENOLIC-COMPOUNDS | - |
dc.subject | CELLS | - |
dc.subject | BARK | - |
dc.subject | APOPTOSIS | - |
dc.subject | EXPRESSION | - |
dc.subject | FLAVONOIDS | - |
dc.title | Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309897100039 | - |
dc.identifier.doi | 10.1016/j.fct.2012.07.014 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.50, no.10, pp.3680 - 3686 | - |
dc.identifier.scopusid | 2-s2.0-84865493001 | - |
dc.citation.endPage | 3686 | - |
dc.citation.startPage | 3680 | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Tilia amurensis | - |
dc.subject.keywordAuthor | Tiliaceae | - |
dc.subject.keywordAuthor | Lignan | - |
dc.subject.keywordAuthor | Antitumor | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordPlus | INDONESIAN MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | SCHISANDRA-CHINENSIS | - |
dc.subject.keywordPlus | NEOLIGNAN GLYCOSIDES | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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