RNA-binding properties and RNA chaperone activity of human peroxiredoxin 1
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji-Hee | - |
dc.contributor.author | Lee, Jeong-Mi | - |
dc.contributor.author | Lee, Hae Na | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Ha, Bin | - |
dc.contributor.author | Ahn, Sung-Min | - |
dc.contributor.author | Jang, Ho Hee | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.date.available | 2020-02-29T05:43:05Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-09-07 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16158 | - |
dc.description.abstract | Human peroxiredoxin 1 (hPrx1), a member of the peroxiredoxin family, detoxifies peroxide substrates and has been implicated in numerous biological processes, including cell growth, proliferation, differentiation, apoptosis, and redox signaling. To date, Prx1 has not been implicated in RNA metabolism. Here, we investigated the ability of hPrx1 to bind RNA and act as an RNA chaperone. In vitro, hPrx1 bound to RNA and DNA, and unwound nucleic acid duplexes. hPrx1 also acted as a transcription anti-terminator in an assay using an Escherichia coli strain containing a stem-loop structure upstream of the chloramphenicol resistance gene. The overall cellular level of hPrx1 expression was not increased at low temperatures, but the nuclear level of hPrx1 was increased. In addition, hPrx1 overexpression enhanced the survival of cells exposed to cold stress, whereas hPrx1 knockdown significantly reduced cell survival under the same conditions. These findings suggest that hPrx1 may perform biological functions as a RNA-binding protein, which are distinctive from known functions of hPrx1 as a reactive oxygen species scavenger. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | COLD-SHOCK PROTEIN | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CELLS | - |
dc.subject | CSPA | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PEROXIDASE | - |
dc.subject | PAG | - |
dc.title | RNA-binding properties and RNA chaperone activity of human peroxiredoxin 1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309017700006 | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.07.142 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.425, no.4, pp.730 - 734 | - |
dc.identifier.scopusid | 2-s2.0-84865968051 | - |
dc.citation.endPage | 734 | - |
dc.citation.startPage | 730 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 425 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kim, Ji-Hee | - |
dc.contributor.affiliatedAuthor | Lee, Jeong-Mi | - |
dc.contributor.affiliatedAuthor | Lee, Hae Na | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Ha, Bin | - |
dc.contributor.affiliatedAuthor | Ahn, Sung-Min | - |
dc.contributor.affiliatedAuthor | Jang, Ho Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Human peroxiredoxin 1 | - |
dc.subject.keywordAuthor | RNA-binding activity | - |
dc.subject.keywordAuthor | RNA chaperone | - |
dc.subject.keywordAuthor | RNA-binding protein | - |
dc.subject.keywordAuthor | Cold stress | - |
dc.subject.keywordPlus | COLD-SHOCK PROTEIN | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CSPA | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PEROXIDASE | - |
dc.subject.keywordPlus | PAG | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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