The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice
DC Field | Value | Language |
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dc.contributor.author | Cai, Mudan | - |
dc.contributor.author | Phan, Phuong-Thuy T. | - |
dc.contributor.author | Hong, Jin Gyu | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Kim, Jong Min | - |
dc.contributor.author | Park, Se Jin | - |
dc.contributor.author | Liu, Xiaotong | - |
dc.contributor.author | Han, Jeong Eun | - |
dc.contributor.author | Park, Haeil | - |
dc.contributor.author | Choi, Ji Woong | - |
dc.contributor.author | Ryu, Jong Hoon | - |
dc.date.available | 2020-02-29T05:44:46Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-08-15 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16231 | - |
dc.description.abstract | Eupatilin, a pharmacologically active flavone derived from the Artemisia plant species, has been reported to have anti-oxidant, anti-inflammatory, anti-allergic, and anti-tumor activities. In the present study, we investigated whether eupatilin exhibits neuroprotective activities against ischemia/reperfusion-induced delayed neuronal injury in mice. Transient global cerebral ischemia was induced in mice by bilateral common carotid artery occlusion (BCCAO) for 15 min followed by reperfusion for 4 days. Eupatilin (1, 3, or 10 mg/kg, p.o.) was administered immediately after the reperfusion. Histochemical studies showed that eupatilin (10 mg/kg) increased the number of viable cells detected by Nissl staining and decreased the number of degenerating neuronal cells detected by Fluoro-Jade B staining in the hippocampal CA1 region. Western blotting indicated that eupatilin further increased the level of Akt phosphorylation at 8 h after BCCAO. Furthermore, wortmannin, a phosphatidylinositol 3-kinase inhibitor, attenuated the eupatilin-induced increase of Akt phosphorylation. In addition, wortmannin completely reversed the eupatilin-induced neuroprotective effects observed at 4 days after reperfusion. These findings suggest that eupatilin is a promising therapeutic agent against global cerebral ischemia-induced neuronal damage and that its neuroprotective effects may be mediated in part by increased Akt phosphorylation. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.subject | GLOBAL CEREBRAL-ISCHEMIA | - |
dc.subject | GASTRIC EPITHELIAL-CELLS | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | BRAIN | - |
dc.subject | RAT | - |
dc.subject | PROTECTS | - |
dc.subject | INJURY | - |
dc.subject | SURVIVAL | - |
dc.subject | DEGENERATION | - |
dc.title | The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000306646900014 | - |
dc.identifier.doi | 10.1016/j.ejphar.2012.05.042 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.689, no.1-3, pp.104 - 110 | - |
dc.identifier.scopusid | 2-s2.0-84864281660 | - |
dc.citation.endPage | 110 | - |
dc.citation.startPage | 104 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 689 | - |
dc.citation.number | 1-3 | - |
dc.contributor.affiliatedAuthor | Choi, Ji Woong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Eupatilin | - |
dc.subject.keywordAuthor | Transient global ischemia | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Akt signaling | - |
dc.subject.keywordPlus | GLOBAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | GASTRIC EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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