Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure
DC Field | Value | Language |
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dc.contributor.author | Maeng, Han-Joo | - |
dc.contributor.author | Shim, Won-Sik | - |
dc.contributor.author | Ahn, Sun-Joo | - |
dc.contributor.author | Yu, Sang-Soo | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.contributor.author | Shim, Chang-Koo | - |
dc.contributor.author | Chung, Suk-Jae | - |
dc.date.available | 2020-02-29T05:45:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16249 | - |
dc.description.abstract | We studied the impact of experimental kidney failure on the pharmacokinetics of a model organic cation and investigated the underlying mechanism(s) of the organic cation transporters. The systemic pharmacokinetics and tissue distribution of triethylmethylammonium (TEMA), a model organic cation, were characterized after intravenous doses of 0.3-30 mu mol/kg in rats with or without uranyl nitrate-induced acute renal failure (UN-ARF). To study the effect of endogenous substrates in plasma from UN-ARF rats on organic cation transport, rOCT- or rOCT2-dependent uptake of tetraethylammonium (TEA) was studied in rOCT1-transfected or rOCT2-transfected LLC-PK1 cells, respectively. As a result, the AUC for TEMA was increased, probably because of decreased total clearance, and the tissue-to-plasma concentration ratio (T/P ratio) of TEMA was unchanged in the liver but decreased significantly in the kidneys of UN-ARF rats. In vitro, the uptake of TEA was decreased significantly by adding UN-ARF plasma, compared with control plasma, in rOCT2-overexpressing LLC-PK1 cells, but not in rOCT1-overexpressing LLC-PK1 cells. These observations suggest that the induction of UN-ARF leads to an accumulation of endogenous organic cation(s), probably rOCT2 substrate(s), in the plasma, thereby affecting the TEMA pharmacokinetics and distribution to the kidneys in rats. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.subject | PARA-AMINOHIPPURATE | - |
dc.subject | TETRAETHYLAMMONIUM | - |
dc.subject | KIDNEY | - |
dc.subject | DISPOSITION | - |
dc.subject | MEMBRANES | - |
dc.title | Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000308244800015 | - |
dc.identifier.doi | 10.1007/s12272-012-0814-3 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.35, no.8, pp.1441 - 1448 | - |
dc.identifier.kciid | ART001686338 | - |
dc.identifier.scopusid | 2-s2.0-84868125647 | - |
dc.citation.endPage | 1448 | - |
dc.citation.startPage | 1441 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Shim, Won-Sik | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Uranyl nitrate-induced acute renal failure (UN-ARF) | - |
dc.subject.keywordAuthor | Organic cation | - |
dc.subject.keywordAuthor | Plasma | - |
dc.subject.keywordAuthor | rOCT2 | - |
dc.subject.keywordAuthor | LLC-PK1 | - |
dc.subject.keywordPlus | PARA-AMINOHIPPURATE | - |
dc.subject.keywordPlus | TETRAETHYLAMMONIUM | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | DISPOSITION | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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