Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors
DC Field | Value | Language |
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dc.contributor.author | Suh, Jeehee | - |
dc.contributor.author | Yum, Eul Kgun | - |
dc.contributor.author | Cheon, Hyae Gyeong | - |
dc.contributor.author | Cho, Young Sik | - |
dc.date.available | 2020-02-29T05:46:31Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1747-0277 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16300 | - |
dc.description.abstract | Biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives was examined for anti-inflammatory activity in in vitro and in vivo assays. The thiazole compounds showed direct inhibition of 5-lipoxygenase (LOX) that is a key enzyme of leukotrienes synthesis and involved in the inflammation-related diseases, including asthma and rheumatoid arthritis. To optimize biological activity, we synthesized 1,3-thiazole-2-amine derivatives and investigated for structure and activity relationship. Especially, N-(3,5-dimethylphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine was shown to have a potent anti-inflammatory activity as a 5-LOX inhibitor. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | CHEMICAL BIOLOGY & DRUG DESIGN | - |
dc.subject | INFLAMMATORY MEDIATORS | - |
dc.subject | COX-2 INHIBITORS | - |
dc.subject | LEUKOTRIENES | - |
dc.subject | ASTHMA | - |
dc.subject | CELLS | - |
dc.subject | 12-LIPOXYGENASE | - |
dc.subject | LEUKOCYTES | - |
dc.subject | HEART | - |
dc.subject | ASSAY | - |
dc.title | Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000304990200010 | - |
dc.identifier.doi | 10.1111/j.1747-0285.2012.01371.x | - |
dc.identifier.bibliographicCitation | CHEMICAL BIOLOGY & DRUG DESIGN, v.80, no.1, pp.90 - 99 | - |
dc.identifier.scopusid | 2-s2.0-84862138672 | - |
dc.citation.endPage | 99 | - |
dc.citation.startPage | 90 | - |
dc.citation.title | CHEMICAL BIOLOGY & DRUG DESIGN | - |
dc.citation.volume | 80 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Cheon, Hyae Gyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 5-lipoxygenase | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | leukotriene B4 | - |
dc.subject.keywordAuthor | neutrophil | - |
dc.subject.keywordAuthor | thiazole scaffold | - |
dc.subject.keywordPlus | INFLAMMATORY MEDIATORS | - |
dc.subject.keywordPlus | COX-2 INHIBITORS | - |
dc.subject.keywordPlus | LEUKOTRIENES | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | 12-LIPOXYGENASE | - |
dc.subject.keywordPlus | LEUKOCYTES | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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