Insulin-like growth factor binding protein-3 suppresses vascular endothelial growth factor expression and tumor angiogenesis in head and neck squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Oh, Seung-Hyun | - |
dc.contributor.author | Kim, Woo-Young | - |
dc.contributor.author | Lee, Ok-Hee | - |
dc.contributor.author | Kang, Ju-Hee | - |
dc.contributor.author | Woo, Jong-Kyu | - |
dc.contributor.author | Kim, Jai-Hyun | - |
dc.contributor.author | Glisson, Bonnie | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.date.available | 2020-02-29T05:46:32Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16302 | - |
dc.description.abstract | Angiogenesis, the process by which new blood vessels are recruited to existing ones, is essential for tumor development. Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), which modulates bioavailability of IGF, has been studied for its potential role in angiogenesis during tissue regeneration and cancer development. In this study, we assessed the role of IGFBP-3 in tumor angiogenesis in head and neck squamous cell carcinoma (HNSCC) and human umbilical vein endothelial cells (HUVECs) using adenoviral (Ad-BP3) and recombinant (rBP3) IGFBP-3. Using an in vivo orthotopic tongue tumor model, we confirmed that both Ad-BP3 and rBP3 suppress the growth of UMSCC38 HNSCC cells in vivo. Ad-BP3 inhibited vascularization in tongue tumors and chorio-allantoic membrane, and suppressed angiogenesis-stimulating activities in UMSCC38 cells. In HUVECs, Ad-BP3 decreased migration, invasion, and tube formation. rBP3 also suppressed production of vascular endothelial growth factor (VEGF) in HUVECs and UMSCC38 cells. IGFBP-3-GGG, a mutant IGFBP-3 with loss of IGF binding capacity, suppressed VEGF production. In addition, we found that IGFBP-3 suppressed VEGF expression, even in mouse embryonic fibroblasts from an IGF-1R-null mouse. Finally, we demonstrated that IGFBP-3-GGG inhibits tumor angiogenesis and growth to the same degree as wild-type IGFBP-3. Taken together, these results support the hypothesis that IGFBP-3 has anti-angiogenic activity in HNSCC, at least in part due to IGF-independent suppression of VEGF production from vascular endothelial cells and cancer cells. (Cancer Sci 2012; 103: 12591266) | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | CANCER SCIENCE | - |
dc.subject | FACTOR-I | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | MULTIPLE-MYELOMA | - |
dc.subject | LUNG-CANCER | - |
dc.subject | INHIBITION | - |
dc.subject | APOPTOSIS | - |
dc.subject | SURVIVAL | - |
dc.subject | IGFBP-3 | - |
dc.subject | PATHWAY | - |
dc.subject | IDENTIFICATION | - |
dc.title | Insulin-like growth factor binding protein-3 suppresses vascular endothelial growth factor expression and tumor angiogenesis in head and neck squamous cell carcinoma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000305888800014 | - |
dc.identifier.doi | 10.1111/j.1349-7006.2012.02301.x | - |
dc.identifier.bibliographicCitation | CANCER SCIENCE, v.103, no.7, pp.1259 - 1266 | - |
dc.identifier.scopusid | 2-s2.0-84863337165 | - |
dc.citation.endPage | 1266 | - |
dc.citation.startPage | 1259 | - |
dc.citation.title | CANCER SCIENCE | - |
dc.citation.volume | 103 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Oh, Seung-Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FACTOR-I | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | IGFBP-3 | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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