Cycloartane-Type Triterpenes from the Leaves of Homonoia riparia with VEGF-Induced Angiogenesis Inhibitory Activity
DC Field | Value | Language |
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dc.contributor.author | Lee, Iksoo | - |
dc.contributor.author | Kim, Junghyun | - |
dc.contributor.author | Kim, Young Sook | - |
dc.contributor.author | Yoo, Nam Hee | - |
dc.contributor.author | Kim, Chan-Sik | - |
dc.contributor.author | Jo, Kyuhyung | - |
dc.contributor.author | Kim, Joo-Hwan | - |
dc.contributor.author | Tran The Bach | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.date.available | 2020-02-29T05:46:51Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16313 | - |
dc.description.abstract | Six new cycloartane-type triterpenes (1-6), 24-methylenecydoartane-3 beta,6 beta,7 beta-triol (1), 24-methylenecycloartane-3 beta,6 beta,7 beta,16 beta-tetraol (2), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol (3), 24-methylenecycloartane-3 beta,7 beta,16 beta-triol 3-O-beta-D-xylopyranoside (4), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol 3-O-beta-D-xylopyranoside (5), and 24-methylenecycloartane-3 beta,6 beta,7 beta-triol 3-O-beta-D-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartarie-3 beta,6 beta,7 beta,16 beta-tetraol 3-O-beta-D-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | 3,4-SECO-CYCLOARTANE TRITERPENES | - |
dc.subject | GLYCOSIDES | - |
dc.title | Cycloartane-Type Triterpenes from the Leaves of Homonoia riparia with VEGF-Induced Angiogenesis Inhibitory Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000306783500009 | - |
dc.identifier.doi | 10.1021/np300224k | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.75, no.7, pp.1312 - 1318 | - |
dc.identifier.scopusid | 2-s2.0-84864274581 | - |
dc.citation.endPage | 1318 | - |
dc.citation.startPage | 1312 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 75 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Joo-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | 3,4-SECO-CYCLOARTANE TRITERPENES | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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