Mutated IDH1 Is a Favorable Prognostic Factor for Type 2 Gliomatosis Cerebri
DC Field | Value | Language |
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dc.contributor.author | Kwon, Mi Jung | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Kwon, Mi Jeong | - |
dc.contributor.author | Kong, Doo-Sik | - |
dc.contributor.author | Lee, Dageun | - |
dc.contributor.author | Park, Sanghui | - |
dc.contributor.author | Kang, So Young | - |
dc.contributor.author | Song, Ji-Young | - |
dc.contributor.author | Nam, Do-Hyun | - |
dc.contributor.author | Kato, Yukinari | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Suh, Yeon-Lim | - |
dc.date.available | 2020-02-29T05:49:22Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1015-6305 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16407 | - |
dc.description.abstract | The prognostic significance of IDH1 mutations has been demonstrated in gliomas. It is unclear whether IDH1 mutation is also a prognostic factor in gliomatosis cerebri (GC). Primary GCs can be grouped into type 1 GCs, which have the classical diffuse growth pattern without mass formation, and type 2 GCs, which form neoplastic masses in addition to classic diffuse lesions. In this study, the prognostic relevance of IDH1/2 mutations in 74 GCs (43 type 1 and 31 type 2) was evaluated. We detected 33 (44.6%) IDH1 mutations, including R132H and R132S, by bidirectional Sanger sequencing. No mutations were detected in IDH2. The percentage of 2-year overall survival for wild-type IDH1 patients was 46 vs. 72% for patients with IDH1-mutated tumors. Mutations of IDH1 were strongly correlated with both increased overall survival (OS) and progression-free survival (PFS) in patients with type 2 GCs, and IDH1 mutations were also an independent prognostic factor predicting increased OS and PFS in type 2 GC patients in multivariate analysis. However, IDH1 mutations did not correlate with survival outcomes in patients with type 1 GCs. Finally, the subgroup of GC, which has IDH1 wild-type and additional solid component showed the worst prognosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | BRAIN PATHOLOGY | - |
dc.subject | MALIGNANT GLIOMAS | - |
dc.subject | TEMOZOLOMIDE | - |
dc.subject | HETEROGENEITY | - |
dc.subject | GLIOBLASTOMA | - |
dc.subject | MUTATIONS | - |
dc.subject | BIOMARKER | - |
dc.title | Mutated IDH1 Is a Favorable Prognostic Factor for Type 2 Gliomatosis Cerebri | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000302704900004 | - |
dc.identifier.doi | 10.1111/j.1750-3639.2011.00532.x | - |
dc.identifier.bibliographicCitation | BRAIN PATHOLOGY, v.22, no.3, pp.307 - 317 | - |
dc.identifier.scopusid | 2-s2.0-84859800560 | - |
dc.citation.endPage | 317 | - |
dc.citation.startPage | 307 | - |
dc.citation.title | BRAIN PATHOLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Park, Sanghui | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | gliomatosis cerebri | - |
dc.subject.keywordAuthor | IDH1 | - |
dc.subject.keywordAuthor | IDH2 | - |
dc.subject.keywordAuthor | mutations | - |
dc.subject.keywordAuthor | prognostic factor | - |
dc.subject.keywordPlus | MALIGNANT GLIOMAS | - |
dc.subject.keywordPlus | TEMOZOLOMIDE | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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