Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocin-induced Diabetic Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Eun-Young | - |
dc.contributor.author | Kim, Ha-Jung | - |
dc.contributor.author | Kim, Yong-Kyoung | - |
dc.contributor.author | Park, Sang-Un | - |
dc.contributor.author | Choi, Jae-Eul | - |
dc.contributor.author | Cha, Ji-Young | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-02-29T06:42:50Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16464 | - |
dc.description.abstract | Panax-ginseng has long been used as a traditional herbal medicine. More recently, it has received attention for its anti-diabetic and anti-obesity effects in humans and in animal models of type 2 diabetes. In the present study, we tested the hypoglycemic effects of ginseng berry extract in beta-cell-deficient mice and investigated the mechanisms involved. Red (ripe) and green (unripe) berry extracts were prepared and administered orally (100 or 200 mg/kg body weight) to streptozotocin-induced diabetic mice daily for 10 wk. The body weight was measured daily, and the nonfasting blood glucose levels were measured after 5 and 10 wk after administration. Glucose tolerance tests were performed, and the serum insulin levels were measured. The proliferation of beta-cells was measured in vitro. The administration of red or green ginseng berry extract significantly reduced the blood glucose levels and improved the glucose tolerance in beta-cell deficient mice, with the higher doses resulting in better effects. Glucose-stimulated insulin secretion was significantly increased in berry extract-treated mice compared with streptozotocin-induced diabetic control mice. Treatment with ginseng berry extract increased beta-cell proliferation in vitro. Both red berry and green berry extracts improved glycemic control in streptozotocin-induced diabetic mice and increased insulin secretion, possibly due to increased beta-cell proliferation. These results suggest that ginseng berry extracts might have beneficial effects on beta-cell regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.relation.isPartOf | JOURNAL OF GINSENG RESEARCH | - |
dc.title | Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocin-induced Diabetic Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000302892700004 | - |
dc.identifier.doi | 10.5142/jgr.2012.36.2.153 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, v.36, no.2, pp.153 - 160 | - |
dc.identifier.kciid | ART001652325 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84859620280 | - |
dc.citation.endPage | 160 | - |
dc.citation.startPage | 153 | - |
dc.citation.title | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Eun-Young | - |
dc.contributor.affiliatedAuthor | Kim, Ha-Jung | - |
dc.contributor.affiliatedAuthor | Cha, Ji-Young | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Panax ginsneg | - |
dc.subject.keywordAuthor | Red ginseng berry | - |
dc.subject.keywordAuthor | Green ginseng berry | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Beta-cell proliferation | - |
dc.subject.keywordPlus | KOREAN RED GINSENG | - |
dc.subject.keywordPlus | AMERICAN GINSENG | - |
dc.subject.keywordPlus | POSTPRANDIAL GLYCEMIA | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | PRESERVATION | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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