Clinical and Microbiologic Characteristics of Cephalosporin-Resistant Escherichia coli at Three Centers in the United States
DC Field | Value | Language |
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dc.contributor.author | Park, Yoon Soo | - |
dc.contributor.author | Adams-Haduch, Jennifer M. | - |
dc.contributor.author | Shutt, Kathleen A. | - |
dc.contributor.author | Yarabinec, Daniel M., III | - |
dc.contributor.author | Johnson, Laura E. | - |
dc.contributor.author | Hingwe, Ameet | - |
dc.contributor.author | Lewis, James S., II | - |
dc.contributor.author | Jorgensen, James H. | - |
dc.contributor.author | Doi, Yohei | - |
dc.date.available | 2020-02-29T06:43:01Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16476 | - |
dc.description.abstract | We investigated the clinical and microbiologic features of 300 cases of cephalosporin-resistant Escherichia coli producing extended-spectrum P-lactamase (ESBL) or plasmid-mediated AmpC beta-lactamase (pAmpC) at three medical centers in the United States. Solid-organ malignancy, connective tissue disease, and a recent history of surgery were more common among pAmpC-producing cases (n = 49), whereas urinary catheter at enrollment, diabetes, and hospitalization in the past year were more common among ESBL-producing cases (n = 233). The factors independently associated with clinical outcome were the following: the presence of cardiovascular disease (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.29 to 6.43), intra-abdominal infection (OR, 6.35; 95% CI, 1.51 to 26.7), other or multiples sources of infection (OR, 8.12; 95% CI, 2.3 to 28.6), age of 65 years or greater (OR, 0.43; 95% CI, 0.2 to 0.95), favorable baseline health status (OR, 0.39; 95% CI, 0.16 to 0.95), and appropriate empirical antimicrobial therapy given in the first 72 h (OR, 0.42; 95% CI, 0.20 to 0.88). beta-Lactamase genes responsible for cephalosporin resistance were identified in 291 cases. CTX-M-type ESBLs accounted for 72.0%. Of those, 88.0% were CTX-M-15. The next most common type was CMY-type pAmpC (16.7%), followed by SHV- and TEM-type ESBLs (6.3 and 1.3%, respectively). Seven cases (2.3%) had KPC-type beta-lactamase. Ertapenem, imipenem, meropenem, doripenem, piperacillin-tazobactam, amikacin, nitrofurantoin, and tigecycline were highly active, with greater than 90% of the isolates being susceptible. Cefepime was less active, with only 74.2% being susceptible due to the predominance of CTX-M-15. These findings have implications in the selection of appropriate empirical therapy when infection due to cephalosporin-resistant E. coli is suspected. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.subject | SPECTRUM BETA-LACTAMASES | - |
dc.subject | INFECTIONS | - |
dc.subject | ENTEROBACTERIACEAE | - |
dc.title | Clinical and Microbiologic Characteristics of Cephalosporin-Resistant Escherichia coli at Three Centers in the United States | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000301898500025 | - |
dc.identifier.doi | 10.1128/AAC.05650-11 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.56, no.4, pp.1870 - 1876 | - |
dc.identifier.scopusid | 2-s2.0-84863342359 | - |
dc.citation.endPage | 1876 | - |
dc.citation.startPage | 1870 | - |
dc.citation.title | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Yoon Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SPECTRUM BETA-LACTAMASES | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | ENTEROBACTERIACEAE | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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