Imatinib efficacy by tumor genotype in Korean patients with advanced gastrointestinal stromal tumors (GIST): The Korean GIST Study Group (KGSG) study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Hye Jin | - |
dc.contributor.author | Ryu, Min-Hee | - |
dc.contributor.author | Kim, Kyoung-Mee | - |
dc.contributor.author | Park, Young Soo | - |
dc.contributor.author | Choi, Jene | - |
dc.contributor.author | Ryoo, Baek-Yeol | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Park, Se Hoon | - |
dc.contributor.author | Lee, Jae-Hyuk | - |
dc.contributor.author | Chung, Ik Joo | - |
dc.contributor.author | Bae, Han-Ik | - |
dc.contributor.author | Kim, Jong Gwang | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Song, Hong Suk | - |
dc.contributor.author | Kwon, Hyuk-Chan | - |
dc.contributor.author | Baek, Jin Ho | - |
dc.contributor.author | Shin, Dong Bok | - |
dc.contributor.author | Lee, Kyoung Eun | - |
dc.contributor.author | Kang, Yoon-Koo | - |
dc.date.available | 2020-02-29T06:43:03Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0284-186X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16478 | - |
dc.description.abstract | Purpose. To assess the efficacy of imatinib for different tumor genotypes in Korean patients with advanced gastrointestinal stromal tumors (GIST). Material and methods. Clinical data were collected from 370 consecutive patients with locally advanced unresectable, metastatic, or recurrent GIST treated with imatinib 400 mg/day between August 2001 and December 2007 at 20 Korean institutions. Tumor genotypes were determined for 290 patients by direct DNA sequencing of KIT exons 9, 11, 13, and 17, and PDGFRA exons 12, 14, and 18. Results. Of 290 patients assessed for genotype, 261 (90.0%) had mutations in KIT : 222 (76.6%) in exon 11, 35 (12.1%) in exon 9 and two each (0.7%) for exons 13 and 17. Four patients (1.4%) had mutations in the PDGFRA gene: one in exon 12, and three in exon 18. Twenty-five patients (8.6%) had no detectable mutations. The best responses of the 235 patients with measurable lesions were: 15 complete response (6.4%), 126 partial response (53.5%), 86 stable disease (36.6%), and eight progressive disease (3.4%). Patients with KIT exon 9 mutations, compared with patients with KIT exon 11 mutations, had a lower objective response rate (36.7% vs. 63.6%, p = 0.007) and a shorter progression-free survival (median 28.7 months vs. 49.4 months, p = 0.001). No statistical difference in overall survival was observed between these genotypes. Conclusion. This study confirms that imatinib efficacy is dependent on genotype in Korean GIST patients, consistent with results demonstrated by Western patients with GIST. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.relation.isPartOf | ACTA ONCOLOGICA | - |
dc.subject | TYROSINE KINASE INHIBITOR | - |
dc.subject | OF-FUNCTION MUTATIONS | - |
dc.subject | C-KIT MUTATION | - |
dc.subject | RANDOMIZED-TRIAL | - |
dc.subject | DOSE IMATINIB | - |
dc.subject | IN-VITRO | - |
dc.subject | MESYLATE | - |
dc.subject | DIAGNOSIS | - |
dc.subject | GROWTH | - |
dc.subject | PROGRESSION | - |
dc.title | Imatinib efficacy by tumor genotype in Korean patients with advanced gastrointestinal stromal tumors (GIST): The Korean GIST Study Group (KGSG) study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000302732800013 | - |
dc.identifier.doi | 10.3109/0284186X.2011.636753 | - |
dc.identifier.bibliographicCitation | ACTA ONCOLOGICA, v.51, no.4, pp.528 - 536 | - |
dc.identifier.scopusid | 2-s2.0-84859778968 | - |
dc.citation.endPage | 536 | - |
dc.citation.startPage | 528 | - |
dc.citation.title | ACTA ONCOLOGICA | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Shin, Dong Bok | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TYROSINE KINASE INHIBITOR | - |
dc.subject.keywordPlus | OF-FUNCTION MUTATIONS | - |
dc.subject.keywordPlus | C-KIT MUTATION | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | DOSE IMATINIB | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MESYLATE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.