Introducing Parametric Fusion PET/MRI of Primary Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Hyunjin | - |
dc.contributor.author | Wood, David | - |
dc.contributor.author | Hussain, Hero | - |
dc.contributor.author | Meyer, Charles R. | - |
dc.contributor.author | Shah, Rajal B. | - |
dc.contributor.author | Johnson, Timothy D. | - |
dc.contributor.author | Chenevert, Thomas | - |
dc.contributor.author | Piert, Morand | - |
dc.date.available | 2020-02-29T06:43:13Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16483 | - |
dc.description.abstract | We assessed the performance of parametric fusion PET/MRI based on C-11-choline PET/CT and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MRI for the identification of primary prostate cancer. Methods: C-11-choline PET/CT and MRI were performed in 17 patients with untreated primary prostate cancer, followed by prostatectomy. Registration of in vivo imaging with histology was achieved using a mutual-information objective function and by performing ex vivo MRI of the prostatectomy specimen (obtained at 3 T) and whole-mount sectioning with block-face photography as intermediate steps. Data analysis included volumetrically registered whole-mount histology with Gleason scoring, C-11-choline, and ADC data (obtained at 1.5 T). Volumes of interest were defined on the basis of histologically proven tumor tissue to calculate tumor-to-benign prostate background ratios (TBRs) for C-11-choline, ADC, and a derived fusion PET/MRI parameter calculating the quotient of C-11-choline over ADC (P-CHOL/ADC)- Results: Fifty-one tumor nodules were identified at pathology. The TBRs for C-11-choline (P < 0.05) and P-CHOL/ADC < 0.005) were significantly higher in prostate cancers with a Gleason score of >= 3 + 4 than with a Gleason score of 3 + 3 disease and controls. For Gleason >= 3 + 4, the ADC TBRs were significantly lower than controls and Gleason <= 3 + 3 disease (P < 0.05). The absolute value of TBRs obtained from Gleason >= 3 + 4 cancers increased from ADC to C-11-choline PET/CT and from C-11-choline PET/CT to P-CHOL/ADC, with each step being statistically significant. Conclusion: Our data indicate that parametric PET/MRI using P-CHOL/ADC improves lesion-to-background contrast (TBRs) of Gleason >= 3 + 4 disease, compared with C-11-choline PET/CT or diffusion-weighted MRI, and thus hold promise that parametric imaging performed on hybrid PET/MRI may further improve identification and localization of significant primary prostate cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SOC NUCLEAR MEDICINE INC | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.subject | APPARENT DIFFUSION-COEFFICIENT | - |
dc.subject | RADICAL PROSTATECTOMY | - |
dc.subject | C-11-CHOLINE PET/CT | - |
dc.subject | GLEASON SCORE | - |
dc.subject | NEEDLE-BIOPSY | - |
dc.subject | WEIGHTED MRI | - |
dc.subject | 3 T | - |
dc.subject | EXPERIENCE | - |
dc.subject | TUMOR | - |
dc.title | Introducing Parametric Fusion PET/MRI of Primary Prostate Cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000302377300035 | - |
dc.identifier.doi | 10.2967/jnumed.111.091421 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, v.53, no.4, pp.546 - 551 | - |
dc.identifier.scopusid | 2-s2.0-84859381916 | - |
dc.citation.endPage | 551 | - |
dc.citation.startPage | 546 | - |
dc.citation.title | JOURNAL OF NUCLEAR MEDICINE | - |
dc.citation.volume | 53 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Hyunjin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | PET/MRI | - |
dc.subject.keywordAuthor | C-11-choline | - |
dc.subject.keywordAuthor | diffusion-weighted MRI | - |
dc.subject.keywordAuthor | fusion imaging | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordPlus | APPARENT DIFFUSION-COEFFICIENT | - |
dc.subject.keywordPlus | RADICAL PROSTATECTOMY | - |
dc.subject.keywordPlus | C-11-CHOLINE PET/CT | - |
dc.subject.keywordPlus | GLEASON SCORE | - |
dc.subject.keywordPlus | NEEDLE-BIOPSY | - |
dc.subject.keywordPlus | WEIGHTED MRI | - |
dc.subject.keywordPlus | 3 T | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | TUMOR | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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