Relation of Ruptured Plaque Culprit Lesion Phenotype and Outcomes in Patients With ST Elevation Acute Myocardial Infarction
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang Wook | - |
dc.contributor.author | Hong, Young Joon | - |
dc.contributor.author | Mintz, Gary S. | - |
dc.contributor.author | Lee, Sung Yun | - |
dc.contributor.author | Doh, Jun Hyung | - |
dc.contributor.author | Lim, Seong Hoon | - |
dc.contributor.author | Kang, Hyun Jae | - |
dc.contributor.author | Rha, Seung Woon | - |
dc.contributor.author | Kim, Jung Sun | - |
dc.contributor.author | Lee, Wang-Soo | - |
dc.contributor.author | Oh, Seong Jin | - |
dc.contributor.author | Lee, Sahng | - |
dc.contributor.author | Hahn, Joo Yong | - |
dc.contributor.author | Lee, Jin Bae | - |
dc.contributor.author | Bae, Jang Ho | - |
dc.contributor.author | Hur, Seung Ho | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Kim, Young Jo | - |
dc.date.available | 2020-02-29T06:44:17Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-03-15 | - |
dc.identifier.issn | 0002-9149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16519 | - |
dc.description.abstract | We used virtual histology intravascular ultrasound (VU-IVUS) to assess culprit plaque rupture in 172 patients with ST-segment elevation acute myocardial infarction. VH-IVUS-defined thin-capped fibroatheroma (VH-TCFA) had necrotic core (NC) > 10% of plaque area, plaque burden > 40%, and NC in contact with the lumen for >= 3 image slices. Ruptured plaques were present in 72 patients, 61% of which were located in the proximal 30 mm of a coronary artery. Thirty-five were classified as VH-TCFA and 37 as non-VH-TCFA. Vessel size, lesion length, plaque burden, minimal lumen area, and frequency of positive remodeling were similar in VH-TCFA and non-VH-TCFA. However, the NC areas within the rupture sites of VH-TCFAs were larger compared to non-VH-TCFAs (p = 0.002), while fibrofatty plaque areas were larger in non-VH-TCFAs (p < 0.0001). Ruptured plaque cavity size was correlated with distal reference lumen area (r = 0.521, p = 0.00002), minimum lumen area (r = 0.595, p < 0.0001), and plaque area (r = 0.267, p = 0.033). Sensitivity and specificity curve analysis showed that a minimum lumen area of 3.5 mm(2), a distal reference lumen area of 7.5 mm(2), and a maximum NC area of 35% best predicted plaque rupture. Although VH-TCFA (35 of 72) was the most frequent phenotype of plaque rupture in ST-segment elevation myocardial infarction, plaque rupture also occurred in non-VH-TCFA: pathologic intimal thickening (8 of 72), thick-capped fibroatheroma (1 of 72), and fibrotic (14 of 72) and fibrocalcified (14 of 72) plaque. In conclusion, not all culprit plaque ruptures in patients with ST-segment elevation myocardial infarction occur as a result of TCFA rupture; a prominent fibrofatty plaque, especially in a proximal vessel, may be another form of vulnerable plaque. Further study should identify additional factors causing plaque rupture. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109: 794-799) | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | RADIOFREQUENCY DATA-ANALYSIS | - |
dc.subject | INTRAVASCULAR ULTRASOUND | - |
dc.subject | THROMBUS ASPIRATION | - |
dc.subject | VIRTUAL HISTOLOGY | - |
dc.subject | ANGINA-PECTORIS | - |
dc.subject | TISSUE CHARACTERIZATION | - |
dc.subject | VULNERABLE PLAQUE | - |
dc.subject | UNSTABLE ANGINA | - |
dc.subject | DEATH | - |
dc.title | Relation of Ruptured Plaque Culprit Lesion Phenotype and Outcomes in Patients With ST Elevation Acute Myocardial Infarction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000301967500003 | - |
dc.identifier.doi | 10.1016/j.amjcard.2011.10.042 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CARDIOLOGY, v.109, no.6, pp.794 - 799 | - |
dc.identifier.scopusid | 2-s2.0-84857781622 | - |
dc.citation.endPage | 799 | - |
dc.citation.startPage | 794 | - |
dc.citation.title | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 109 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Han, Seung Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | RADIOFREQUENCY DATA-ANALYSIS | - |
dc.subject.keywordPlus | INTRAVASCULAR ULTRASOUND | - |
dc.subject.keywordPlus | THROMBUS ASPIRATION | - |
dc.subject.keywordPlus | VIRTUAL HISTOLOGY | - |
dc.subject.keywordPlus | ANGINA-PECTORIS | - |
dc.subject.keywordPlus | TISSUE CHARACTERIZATION | - |
dc.subject.keywordPlus | VULNERABLE PLAQUE | - |
dc.subject.keywordPlus | UNSTABLE ANGINA | - |
dc.subject.keywordPlus | DEATH | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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