Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm
DC Field | Value | Language |
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dc.contributor.author | Cinghu, Senthilkumar | - |
dc.contributor.author | Goh, Yun-Mi | - |
dc.contributor.author | Oh, Byung-Chul | - |
dc.contributor.author | Lee, You-Soub | - |
dc.contributor.author | Lee, Ok-Jun | - |
dc.contributor.author | Devaraj, Halagowder | - |
dc.contributor.author | Bae, Suk-Chul | - |
dc.date.available | 2020-02-29T06:44:29Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16525 | - |
dc.description.abstract | As H. pylori infection progresses, intestinal metaplasia (IM), a key event in gastric carcinogenesis, develops in the stomach. The mechanism by which H. pylori infection causes the trans-differentiation of gastric cells to intestinal-type cells remains an important question. In the current study, we found that RUNX3 is deregulated in all human IM specimens examined by either down regulation or mislocalization; Aberrant localization of a gastric tumor suppressor RUNX3 is observed in most human cases of IM with concurrent H. pylori infection, and RUNX3 is down-regulated in most cases of IM without H. pylori-infection. The cytoplasmic mislocalization of a RUNX3 was associated with H. pylori-induced c-Src activation and RUNX tyrosine phosphorylation. Moreover, gastric epithelial cells of Runx3-/- mice expressed the intestinal markers Muc2 and Li-Cadherin, which suggests that the deregulation of Runx3 is a key event in the intestinalization of the gastric epithelium. Collectively, the results of the current study suggest that RUNX3 deregulation is associated with H. pylori-induced pathogenesis and the development of IM. J. Cell. Physiol. 227: 10711080, 2012. (C) 2011 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.subject | INTESTINAL METAPLASIA | - |
dc.subject | HELICOBACTER-PYLORI | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | STOMACH-CANCER | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEIN | - |
dc.subject | GENES | - |
dc.subject | MICE | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | PATHOLOGY | - |
dc.title | Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000298484800020 | - |
dc.identifier.doi | 10.1002/jcp.22820 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.227, no.3, pp.1071 - 1080 | - |
dc.identifier.scopusid | 2-s2.0-84155178030 | - |
dc.citation.endPage | 1080 | - |
dc.citation.startPage | 1071 | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 227 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Goh, Yun-Mi | - |
dc.contributor.affiliatedAuthor | Oh, Byung-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTESTINAL METAPLASIA | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | STOMACH-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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