Genetic Susceptibility on CagA-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jae Jeong | - |
dc.contributor.author | Cho, Lisa Y. | - |
dc.contributor.author | Ko, Kwang-Pil | - |
dc.contributor.author | Shin, Aesun | - |
dc.contributor.author | Ma, Seung Hyun | - |
dc.contributor.author | Choi, Bo Youl | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Song, Kyu Sang | - |
dc.contributor.author | Kim, Yong Sung | - |
dc.contributor.author | Lee, Jong-Young | - |
dc.contributor.author | Han, Bok Ghee | - |
dc.contributor.author | Chang, Soung-Hoon | - |
dc.contributor.author | Shin, Hai-Rim | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.available | 2020-02-29T06:45:38Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-02-24 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16577 | - |
dc.description.abstract | Objectives: To evaluate whether genes that encode CagA-interacting molecules (SRC, PTPN11, CRK, CRKL, CSK, c-MET and GRB2) are associated with gastric cancer risk and whether an interaction between these genes and phytoestrogens modify gastric cancer risk. Methods: In the discovery phase, 137 candidate SNPs in seven genes were analyzed in 76 incident gastric cancer cases and 322 matched controls from the Korean Multi-Center Cancer Cohort. Five significant SNPs in three genes (SRC, c-MET and CRK) were re-evaluated in 386 cases and 348 controls in the extension phase. Odds ratios (ORs) for gastric cancer risk were estimated adjusted for age, smoking, H. pylori seropositivity and CagA strain positivity. Summarized ORs in the total study population (462 cases and 670 controls) were presented using pooled-and meta-analysis. Plasma concentrations of phytoestrogens (genistein, daidzein, equol and enterolactone) were measured using the time-resolved fluoroimmunoassay. Results: SRC rs6122566, rs6124914, c-MET rs41739, and CRK rs7208768 showed significant genetic effects for gastric cancer in both the pooled and meta-analysis without heterogeneity (pooled OR = 3.96 [95% CI 2.05-7.65], 1.24 [95% CI = 1.01-1.53], 1.19 [95% CI = 1.01-1.41], and 1.37 [95% CI = 1.15-1.62], respectively; meta OR = 4.59 [95% CI 2.74-7.70], 1.36 [95% CI = 1.09-1.70], 1.20 [95% CI = 1.00-1.44], and 1.32 [95% CI = 1.10-1.57], respectively). Risk allele of CRK rs7208768 had a significantly increased risk for gastric cancer at low phytoestrogen levels (p interaction<0.05). Conclusions: Our findings suggest that SRC, c-MET and CRK play a key role in gastric carcinogenesis by modulating CagA signal transductions and interaction between CRK gene and phytoestrogens modify gastric cancer risk. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | HELICOBACTER-PYLORI CAGA | - |
dc.subject | PROTEIN | - |
dc.subject | MET | - |
dc.subject | KINASE | - |
dc.subject | CELLS | - |
dc.subject | SRC | - |
dc.subject | ASSOCIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTOR | - |
dc.subject | FAMILY | - |
dc.title | Genetic Susceptibility on CagA-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000302916800008 | - |
dc.identifier.doi | 10.1371/journal.pone.0031020 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.7, no.2 | - |
dc.identifier.scopusid | 2-s2.0-84863157455 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Ko, Kwang-Pil | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI CAGA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MET | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SRC | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | FAMILY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.