Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia
DC Field | Value | Language |
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dc.contributor.author | Koh, Kwang Kon | - |
dc.contributor.author | Quon, Michael J. | - |
dc.contributor.author | Shin, Kwen-Chul | - |
dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Lee, Yonghee | - |
dc.contributor.author | Sakuma, Ichiro | - |
dc.contributor.author | Lee, Kyounghoon | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Shin, Eak Kyun | - |
dc.date.available | 2020-02-29T06:46:08Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16598 | - |
dc.description.abstract | Background: Omega-3 fatty acids and fenofibrate are both used to treat patients with hypertriglyceridemia. However, a head-to-head comparison of the lipoprotein and metabolic effects of these two medicines has not been published. Methods: This was a randomized, single-blind, placebo-controlled, parallel study. Age, sex, and body mass index were matched among groups. All patients were recommended to maintain a low fat diet. Fifty patients in each group were given placebo, omega-3 fatty acids 2 g (most commonly used dosage in Korean patients), or fenofibrate 160 mg, respectively daily for 2 months. Results: Omega-3 fatty acids therapy decreased triglycerides by 21% and triglycerides/HDL cholesterol and improved flow-mediated dilation (P < 0.01), however, did not significantly change insulin, plasma adiponectin levels, and insulin sensitivity (determined by QUICKI) relative to baseline measurements. Fenofibrate therapy decreased total cholesterol, triglycerides by 29%, and triglycerides/HDL-cholesterol (all P < 0.01) and improved flow-mediated dilation when compared with baseline. When compared with placebo and omega-3 fatty acids, fenofibrate therapy decreased non-HDL cholesterol (P < 0.001) and triglycerides/HDL cholesterol (P = 0.016) while increasing HDL cholesterol (P < 0.001) and apolipoprotein AI (P = 0.001). Of note, when compared with omega-3 fatty acids, fenofibrate therapy decreased fasting insulin (P = 0.023) and increased plasma adiponectin (P = 0.002) and insulin sensitivity (P = 0.015). Conclusions: Omega-3 fatty acids and fenofibrate therapy promoted similar changes in triglycerides and endothelium-dependent dilation. However, fenofibrate therapy had substantially better effects on lipoprotein and metabolic profiles in patients with hypertriglyceridemia. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.title | Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000299319100040 | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2011.11.018 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, v.220, no.2, pp.537 - 544 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84855950126 | - |
dc.citation.endPage | 544 | - |
dc.citation.startPage | 537 | - |
dc.citation.title | ATHEROSCLEROSIS | - |
dc.citation.volume | 220 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Koh, Kwang Kon | - |
dc.contributor.affiliatedAuthor | Shin, Kwen-Chul | - |
dc.contributor.affiliatedAuthor | Lee, Kyounghoon | - |
dc.contributor.affiliatedAuthor | Han, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Shin, Eak Kyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Omega-3 fatty acids | - |
dc.subject.keywordAuthor | Fenofibrate | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Hypertriglyceridemia | - |
dc.subject.keywordPlus | ASSESSING INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | RECIPROCAL RELATIONSHIPS | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | EICOSAPENTAENOIC ACID | - |
dc.subject.keywordPlus | METABOLIC PARAMETERS | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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