MOLECULAR MECHANISM OF PANCREATIC AND SALIVARY GLAND FLUID AND HCO3- SECRETION
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min Goo | - |
dc.contributor.author | Ohana, Ehud | - |
dc.contributor.author | Park, Hyun Woo | - |
dc.contributor.author | Yang, Dongki | - |
dc.contributor.author | Muallem, Shmuel | - |
dc.date.available | 2020-02-29T06:46:55Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0031-9333 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16629 | - |
dc.description.abstract | Lee MG, Ohana E, Park HW, Yang D, Muallem S. Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3- Secretion. Physiol Rev 92: 39-74, 2012; doi: 10.1152/physrev.00011.2011.-Fluid and HCO3- secretion is a vital function of all epithelia and is required for the survival of the tissue. Aberrant fluid and HCO3- secretion is associated with many epithelial diseases, such as cystic fibrosis, pancreatitis, Sjogren's syndrome, and other epithelial inflammatory and autoimmune diseases. Significant progress has been made over the last 20 years in our understanding of epithelial fluid and HCO3- secretion, in particular by secretory glands. Fluid and HCO3- secretion by secretory glands is a two-step process. Acinar cells secrete isotonic fluid in which the major salt is NaCl. Subsequently, the duct modifies the volume and electrolyte composition of the fluid to absorb the Cl- and secrete HCO3-. The relative volume secreted by acinar and duct cells and modification of electrolyte composition of the secreted fluids varies among secretory glands to meet their physiological functions. In the pancreas, acinar cells secrete a small amount of NaCl-rich fluid, while the duct absorbs the Cl- and secretes HCO3- and the bulk of the fluid in the pancreatic juice. Fluid secretion appears to be driven by active HCO3- secretion. In the salivary glands, acinar cells secrete the bulk of the fluid in the saliva that is driven by active Cl- secretion and contains high concentrations of Na+ and Cl-. The salivary glands duct absorbs both the Na+ and Cl- and secretes K+ and HCO3-. In this review, we focus on the molecular mechanism of fluid and HCO3- secretion by the pancreas and salivary glands, to highlight the similarities of the fundamental mechanisms of acinar and duct cell functions, and to point out the differences to meet gland-specific secretions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.relation.isPartOf | PHYSIOLOGICAL REVIEWS | - |
dc.subject | TRANSMEMBRANE CONDUCTANCE REGULATOR | - |
dc.subject | PAROTID ACINAR-CELLS | - |
dc.subject | CYSTIC-FIBROSIS GENE | - |
dc.subject | GUINEA-PIG PANCREAS | - |
dc.subject | VASOACTIVE-INTESTINAL-PEPTIDE | - |
dc.subject | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | - |
dc.subject | SODIUM-BICARBONATE COTRANSPORTER | - |
dc.subject | RAT SUBMANDIBULAR-GLAND | - |
dc.subject | DUCT EPITHELIAL-CELLS | - |
dc.subject | CA2+-ACTIVATED K+ CHANNELS | - |
dc.title | MOLECULAR MECHANISM OF PANCREATIC AND SALIVARY GLAND FLUID AND HCO3- SECRETION | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000300048000002 | - |
dc.identifier.doi | 10.1152/physrev.00011.2011 | - |
dc.identifier.bibliographicCitation | PHYSIOLOGICAL REVIEWS, v.92, no.1, pp.39 - 74 | - |
dc.identifier.scopusid | 2-s2.0-84863024166 | - |
dc.citation.endPage | 74 | - |
dc.citation.startPage | 39 | - |
dc.citation.title | PHYSIOLOGICAL REVIEWS | - |
dc.citation.volume | 92 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yang, Dongki | - |
dc.type.docType | Review | - |
dc.subject.keywordPlus | TRANSMEMBRANE CONDUCTANCE REGULATOR | - |
dc.subject.keywordPlus | PAROTID ACINAR-CELLS | - |
dc.subject.keywordPlus | CYSTIC-FIBROSIS GENE | - |
dc.subject.keywordPlus | GUINEA-PIG PANCREAS | - |
dc.subject.keywordPlus | VASOACTIVE-INTESTINAL-PEPTIDE | - |
dc.subject.keywordPlus | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | - |
dc.subject.keywordPlus | SODIUM-BICARBONATE COTRANSPORTER | - |
dc.subject.keywordPlus | RAT SUBMANDIBULAR-GLAND | - |
dc.subject.keywordPlus | DUCT EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CA2+-ACTIVATED K+ CHANNELS | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.