Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Song, Kyu Choon | - |
dc.contributor.author | Chang, Tong-Shin | - |
dc.contributor.author | Lee, Hyejin | - |
dc.contributor.author | Kim, Jinhee | - |
dc.contributor.author | Park, Jeong Hill | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.date.available | 2020-02-29T06:47:03Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16636 | - |
dc.description.abstract | In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.relation.isPartOf | JOURNAL OF GINSENG RESEARCH | - |
dc.subject | HUMAN-SKIN | - |
dc.subject | TISSUE INHIBITOR | - |
dc.subject | DIFFERENTIAL EXPRESSION | - |
dc.subject | EXTRACT | - |
dc.subject | PROLIFERATION | - |
dc.subject | ACID | - |
dc.title | Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000299198800007 | - |
dc.identifier.doi | 10.5142/jgr.2012.36.1.61 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, v.36, no.1, pp.61 - 67 | - |
dc.identifier.kciid | ART001627087 | - |
dc.identifier.scopusid | 2-s2.0-84862931744 | - |
dc.citation.endPage | 67 | - |
dc.citation.startPage | 61 | - |
dc.citation.title | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Song, Kyu Choon | - |
dc.contributor.affiliatedAuthor | Lee, Hyejin | - |
dc.contributor.affiliatedAuthor | Kim, Jinhee | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | Sun ginseng (SE) | - |
dc.subject.keywordAuthor | Type I collagen | - |
dc.subject.keywordAuthor | Matrix metalloproteinase-1 | - |
dc.subject.keywordAuthor | Human skin fibroblasts | - |
dc.subject.keywordPlus | HUMAN-SKIN | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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