Fractional exhaled nitric oxide and forced expiratory flow between 25% and 75% of vital capacity in children with controlled asthma
DC Field | Value | Language |
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dc.contributor.author | Yoon, J.-Y. | - |
dc.contributor.author | Woo, S.-I. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Sun, Y.-H. | - |
dc.contributor.author | Hahn, Y.-S. | - |
dc.date.available | 2020-02-29T06:48:30Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16683 | - |
dc.description.abstract | Purpose: Fractional exhaled nitric oxide (FeNO) and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) are not included in routine monitoring of asthma control. We observed changes in FeNO level and FEF2S-7S after FeNO-based treatment with inhaled corticosteroid (ICS) in children with controlled asthma (CA). Methods: We recruited 148 children with asthma (age, 8 to 16 years) who had maintained asthma control and normal forced expiratory volume in the first second (FEV1) without control medication for >3 months. Patients with FeNO levels >25 ppb were allocated to the ICS- treated (FeNO-based management) or untreated group (guideline-based management). Changes in spirometric values and FeNO levels from baseline were evaluated after 6 weeks. Results: Ninety-three patients had FeNO levels >25 ppb. These patients had lower FEF25-75% predicted values than those with FeNO levels <25 ppb (P<0.01). After 6 weeks, the geometric mean (GM) FeNO level in the ICS-treated group was 45% lower than the baseline value, and the mean percent increase in FEF25-75 was 18.7% which was greater than that in other spirometric values. There was a negative correlation between percent changes in FEF25-75 and FeNO (r=-0.368, P=0.001). In contrast, the GM FeNO and spirometric values were not significantly different from the baseline values in the untreated group. Conclusion: The anti-inflammatory treatment simultaneously improved the FeNO levels and FEF25-75 in CA patients when their FeNO levels were >25 ppb. © 2012 by The Korean Pediatric Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Pediatric Society | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.title | Fractional exhaled nitric oxide and forced expiratory flow between 25% and 75% of vital capacity in children with controlled asthma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.3345/kjp.2012.55.9.380 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, v.55, no.9, pp.372 - 379 | - |
dc.identifier.kciid | ART001742463 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84866482380 | - |
dc.citation.endPage | 379 | - |
dc.citation.startPage | 372 | - |
dc.citation.title | Korean Journal of Pediatrics | - |
dc.citation.volume | 55 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Sun, Y.-H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Inhaled corticosteroids | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Spirometry | - |
dc.subject.keywordPlus | corticosteroid | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | asthma | - |
dc.subject.keywordPlus | body mass | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | forced expiratory flow | - |
dc.subject.keywordPlus | forced expiratory volume | - |
dc.subject.keywordPlus | forced vital capacity | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | lung function test | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | parental smoking | - |
dc.subject.keywordPlus | patient compliance | - |
dc.subject.keywordPlus | preschool child | - |
dc.subject.keywordPlus | school child | - |
dc.subject.keywordPlus | spirometry | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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