시호 추출물의 oxLDL 유도 Foam Cell 형성 억제 작용Inhibitory Effects of Bupleuri Radix on ox-LDL induced Foam Cell Formation
- Other Titles
- Inhibitory Effects of Bupleuri Radix on ox-LDL induced Foam Cell Formation
- Authors
- 이혜진; 배호성; 황귀서
- Issue Date
- 2012
- Publisher
- 대한예방한의학회
- Keywords
- atherosclerosis; Bupleuri radix; LDL oxidation; foam cell; macrophage
- Citation
- 대한예방한의학회지, v.16, no.2, pp.113 - 124
- Journal Title
- 대한예방한의학회지
- Volume
- 16
- Number
- 2
- Start Page
- 113
- End Page
- 124
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16726
- ISSN
- 1226-7066
- Abstract
- The oxidative modification of low density lipoprotein(LDL) has been implicated in the development of atherosclerosis. Oxidized LDL(oxLDL) is captured into macrophage and stimulates to form macrophage foam cell. And it can induce an inflammation and smooth muscle proliferation in atherosclerotic plaque.
Objective: In this study, we aimed to investigate the effect of Bupleuri radix(SH) on the foam cell formation, a critical initiation stage of atherosclerosis.
Methods: To achieve the goal, we examined the effect of SH on LDL oxidation, nitric oxide production in RAW264.7, and the effect of SH on cupuric sulfate-induced cytotoxicity, LDH release, and macrophage activity.
Results: SH inhibited the formation of oxidized LDL from native LDL in RAW264.7 cell culture, and decreased the release of LDH from cupric sulfate-stimulated RAW264.7 cell. In other experiments, SH activated RAW264.7 cell, and prolonged the survival time, and inhibited foam cell formation induced by oxLDL in Raw 264.7 cells.
Conclusion: These results showed that SH might prevent atherosclerosis by controlling the early stages of foam cell formation.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16726)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.