Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 박완수 | - |
dc.date.available | 2020-02-29T07:42:03Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1738-7698 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16758 | - |
dc.description.abstract | The purpose of this study is to investigate the modulatory effect of wogonin on hydrogen peroxide production in human blastoma SH-SY5Y cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Wogonin significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 10, 25, and 50 μM in SH-SY5Y (P < 0.05) in dose dependent manner. These results suggest that wogonin has neuroprotective property related with its inhibition of hydrogen peroxide production in PIC-induced neuronal cells. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한의병리학회 | - |
dc.relation.isPartOf | 동의생리병리학회지 | - |
dc.title | Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향 | - |
dc.title.alternative | Effect of Wogonin on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced Human Neuroblastoma SH-SY5Y Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 동의생리병리학회지, v.26, no.4, pp.491 - 496 | - |
dc.identifier.kciid | ART001686215 | - |
dc.citation.endPage | 496 | - |
dc.citation.startPage | 491 | - |
dc.citation.title | 동의생리병리학회지 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 박완수 | - |
dc.subject.keywordAuthor | Wogonin | - |
dc.subject.keywordAuthor | Neuronal cells | - |
dc.subject.keywordAuthor | DsRNA | - |
dc.subject.keywordAuthor | Hydrogen peroxide | - |
dc.subject.keywordAuthor | Anti-oxidative | - |
dc.description.journalRegisteredClass | kci | - |
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