A tearable dissolving microneedle system for shortening application time
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Won-Jun | - |
dc.contributor.author | Han, Mee-Ree | - |
dc.contributor.author | Kim, Ji-Seok | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.date.available | 2020-02-27T03:42:58Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-03-04 | - |
dc.identifier.issn | 1742-5247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1693 | - |
dc.description.abstract | Objectives: A tearable dissolving microneedle system (TD-MN system) was developed for shortening the time required to administer drugs into the skin through the dissolving microneedles. Methods: TD-MN system consisted of an array of tearable dissolving microneedles (TD-MN) and micro-pillars. The microneedle tips had a female part to integrate with the micro-pillars. The micro-pillars exerted a vertical force to cause the separation of the tips from the base. The separation force exerted by six TD-MN arrays with different thicknesses of separation region was measured. The TD-MN system with trypan blue was inserted into porcine skin to observe the separation of the microneedle tips, and then calcein was added separately to observe drug diffusion into the skin. Results: The thickness of the tearable region and the depth of the female part were a function of the concentration and volume of the molding solution. The separation force increased as the thickness of the tearable region increased. Nine tips were successfully separated from the base by applying a force of through the micro-pillars. Conclusions: The TD-MN system could provide immediate administration of a drug, resulting in improved patient convenience as well as delivery of the correct drug dose. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | EXPERT OPINION ON DRUG DELIVERY | - |
dc.subject | TRANSDERMAL DELIVERY | - |
dc.subject | SEPARABLE MICRONEEDLES | - |
dc.subject | POLYVINYL-ALCOHOL | - |
dc.subject | DRUG | - |
dc.subject | METFORMIN | - |
dc.title | A tearable dissolving microneedle system for shortening application time | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000461429100002 | - |
dc.identifier.doi | 10.1080/17425247.2019.1583645 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON DRUG DELIVERY, v.16, no.3, pp.199 - 206 | - |
dc.identifier.scopusid | 2-s2.0-85062343240 | - |
dc.citation.endPage | 206 | - |
dc.citation.startPage | 199 | - |
dc.citation.title | EXPERT OPINION ON DRUG DELIVERY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Won-Jun | - |
dc.contributor.affiliatedAuthor | Kim, Ji-Seok | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Tearable dissolving microneedles | - |
dc.subject.keywordAuthor | micro-pillars | - |
dc.subject.keywordAuthor | shortened application time | - |
dc.subject.keywordAuthor | rapid separation | - |
dc.subject.keywordAuthor | conventional manufacturing process | - |
dc.subject.keywordPlus | TRANSDERMAL DELIVERY | - |
dc.subject.keywordPlus | SEPARABLE MICRONEEDLES | - |
dc.subject.keywordPlus | POLYVINYL-ALCOHOL | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.