Effects of Red Ginseng-Ejung-tang Water Extract on Cytokine Production in LPS-induced Mouse Macrophages
DC Field | Value | Language |
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dc.contributor.author | 박완수 | - |
dc.date.available | 2020-02-29T07:47:04Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1010-0695 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17011 | - |
dc.description.abstract | Objectives: The purpose of this study was to investigate effects of Red Ginseng-Ejung-tang Water Extract (ER) on cytokine production in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Methods: Levels of various cytokines such as interleukin (IL)-6, IL-10, IL-2, IL-12p70, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-2, keratinocyte-derived chemokine (KC), tumor necrosis factor (TNF)-alpha, granulocyte macrophage colony-stimulating factor (GM-CSF) were measured by high-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results: ER significantly decreased levels of IL-6, IL-10, IL-2, IL-12p70, VEGF, and MCP-1 for 24 hrs incubation at the concentrations of 25, 50, and 100 ㎍/mL in LPS-induced RAW 264.7 cells (P < 0.05). But ER did not exert significant effects on production of MIP-2, KC, TNF-α, and GM-CSF in LPS-induced RAW 264.7 cells. Conclusions: These results suggest that ER has an anti-inflammatory property related with its inhibition of cytokine production in LPS-induced macrophages. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한한의학회 | - |
dc.relation.isPartOf | 대한한의학회지 | - |
dc.title | Effects of Red Ginseng-Ejung-tang Water Extract on Cytokine Production in LPS-induced Mouse Macrophages | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한한의학회지, v.33, no.4, pp.42 - 49 | - |
dc.identifier.kciid | ART001726990 | - |
dc.citation.endPage | 49 | - |
dc.citation.startPage | 42 | - |
dc.citation.title | 대한한의학회지 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 박완수 | - |
dc.subject.keywordAuthor | Red ginseng | - |
dc.subject.keywordAuthor | Ejung-tang | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | cytokine | - |
dc.description.journalRegisteredClass | kci | - |
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