암 치료제를 위한 키토산 올리고머와 골드입자 간의 키토산-골드 나노복합체의 제조The Formation of Nano-composite between Chitosan Oligosaccharides and Gold Nanoparticles for Cancer Therapy
- Other Titles
- The Formation of Nano-composite between Chitosan Oligosaccharides and Gold Nanoparticles for Cancer Therapy
- Authors
- 조익현; 강익중
- Issue Date
- 2012
- Publisher
- 한국키틴키토산학회
- Keywords
- Chitosan oligaccharide; Gold nanoparticle; TPP
- Citation
- Journal of Chitin and Chitosan, v.17, no.3, pp.141 - 146
- Journal Title
- Journal of Chitin and Chitosan
- Volume
- 17
- Number
- 3
- Start Page
- 141
- End Page
- 146
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17090
- ISSN
- 1229-4160
- Abstract
- The careful synthesis of drug carrier is important because it has the property of biodegradable and bio-compatible, and the role of easy and effective release in drug delivery system (DDS). Chitosan oligosaccharide (COS) which produced by the hydrolysis and enzyme degradation of chitin from the crustacean has been recently studied as a medical substrate for anti-cancer agents of DDS. Gold nanoparticles (GNPs) have been used antioxidant and biomaterial for cancer therapy because GNPs have photochemical and light sensitive properties to be applicable to medicinal system. COS-GNPs nano-composite with COS of various cross-linking agent concentration and GNPs of various reducing agent concentration by using interactive force between COS and gold nanaoparticles was prepared in this study. The composition and morphology was confirmed by Transmission electron microscope (TEM), Atomic Force Microscopy (AFM), Ultraviolet-visible spectroscopy, and it was applied to cancer therapy.
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Collections - 공과대학 > 화공생명공학과 > 1. Journal Articles
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