Association Between Serum High-Density Lipoprotein Cholesterol Levels and Progression of Chronic Kidney Disease: Results From the KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | Nam, Ki Heon | - |
dc.contributor.author | Chang, Tae Ik | - |
dc.contributor.author | Joo, Young Su | - |
dc.contributor.author | Kim, Joohwan | - |
dc.contributor.author | Lee, Sangmi | - |
dc.contributor.author | Lee, Changhyun | - |
dc.contributor.author | Yun, Hae-Ryong | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Sung, Su Ah | - |
dc.contributor.author | Lee, Kyu-Beck | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Choi, Kyu Hun | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Park, Soo Kyung | - |
dc.contributor.author | Kim, Jayeon | - |
dc.contributor.author | Chae, Dong Wan | - |
dc.contributor.author | Kim, Yong-Soo | - |
dc.contributor.author | Kim, Yeong Hoon | - |
dc.contributor.author | Kang, Sun Woo | - |
dc.contributor.author | Koo, Ho Seok | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Jung, Jiyong | - |
dc.date.available | 2020-02-27T03:43:09Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1716 | - |
dc.description.abstract | Background-High-density lipoprotein cholesterol (HDL-C) levels are generally decreased in patients with chronic kidney disease (CKD). However, studies on the relationship between HDL-C and CKD progression are scarce. Methods and Results-We studied the association between serum HDL-C levels and the risk of CKD progression in 2168 participants of the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease). The primary outcome was the composite of a 50% decline in estimated glomerular filtration rate from baseline or end-stage renal disease. The secondary outcome was the onset of end-stage renal disease. During a median follow-up of 3.1 (interquartile range, 1.6-4.5) years, the primary outcome occurred in 335 patients (15.5%). In a fully adjusted Cox model, the lowest category with HDL-C of <30 mg/dL (hazard ratio, 2.21; 95% CI, 1.30-3.77) and the highest category with HDL-C of >= 60 mg/dL (hazard ratio, 2.05; 95% CI, 1.35-3.10) were associated with a significantly higher risk of the composite renal outcome, compared with the reference category with HDL-C of 50 to 59 mg/dL. This association remained unaltered in a time-varying Cox analysis. In addition, a fully adjusted cubic spline model with HDL-C being treated as a continuous variable yielded similar results. Furthermore, consistent findings were obtained in a secondary outcome analysis for the development of end-stage renal disease. Conclusions-A U-shaped association was observed between serum HDL-C levels and adverse renal outcomes in this large cohort of patients with CKD. Our findings suggest that both low and high serum HDL-C levels may be detrimental to patients with nondialysis CKD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.title | Association Between Serum High-Density Lipoprotein Cholesterol Levels and Progression of Chronic Kidney Disease: Results From the KNOW-CKD | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000484573500020 | - |
dc.identifier.doi | 10.1161/JAHA.118.011162 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.8, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85062862947 | - |
dc.citation.title | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.contributor.affiliatedAuthor | Jung, Jiyong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | high-density lipoprotein | - |
dc.subject.keywordAuthor | high-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordAuthor | kidney disease progression | - |
dc.subject.keywordPlus | LOW HDL CHOLESTEROL | - |
dc.subject.keywordPlus | RENAL DYSFUNCTION | - |
dc.subject.keywordPlus | MOLECULAR REGULATION | - |
dc.subject.keywordPlus | LDL CHOLESTEROL | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | LIPIDS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | EVENTS | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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