Potential Anti-photoaging Effect of Amino Sugar

Abstract

The anti-photoaging activity of amino sugar was measured by monitoring the survival rate toward a bacterial species Serratia marcescens. Cells incubated in liquid and solid culture medium containing various sugars were irradiated under UV 254 nm or 365 nm. Among sugars tested in this study, relatively high photo-protective activity in the presence of amino sugars such as glucosamine, mannosamine, and galactosamine on cells irradiated under UV 365 nm were observed incubated in liquid culture medium compared to other neutral sugars tested. Especially, glucosamine has displayed the highest photo-protective activity (75%) estimated based on the growth recovery of cells irradiated under UV 365 nm. On the other hands, neutral sugar including glucose, mannose and galactose showed the marginal photo-protective effect on cells irradiated under UV 365 nm. However,both amino sugars and neutral sugars displayed neither photo-protective activities on cells incubated in liquid nor solid agar medium under UV 254 nm. Our results indicate that amino sugars has shown selective absorbing activities toward UV 365 nm and are useful as potentially bioactive anti-photoaging materials in cosmeceutical and pharmaceutical industries.