Activated microglial cells synthesize and secrete AGE-albumin
- Authors
- 변경희; Enkhjaigal Bayarsaikhan; 김대식; Myeongjoo Son; Junhee Hong; 정구보; 백선하; 원무호; 이봉희
- Issue Date
- Mar-2012
- Publisher
- 대한해부학회
- Keywords
- Microglia; AGE albumin; Cell death
- Citation
- Anatomy and Cell Biology, v.45, no.1, pp.47 - 52
- Journal Title
- Anatomy and Cell Biology
- Volume
- 45
- Number
- 1
- Start Page
- 47
- End Page
- 52
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17297
- ISSN
- 2093-3665
- Abstract
- A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.
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Collections - 의과대학 > 의예과 > 1. Journal Articles
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