Clog-free and reliable solvent bonding of poly(methyl methacrylate) microdevice mediated by eco-friendly acetic acid at room temperature and its application for polymerase chain reaction and human cell culture
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Trinh, Kieu The Loan | - |
dc.contributor.author | Pham, Quang Nghia | - |
dc.contributor.author | Lee, Nae Yoon | - |
dc.date.available | 2020-02-27T04:40:37Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-03-01 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1730 | - |
dc.description.abstract | Poly(methyl methacrylate) (PMMA) is one of the most popular thermoplastic materials used for microfluidic fabrication, yet rapid sealing of PMMA microdevices is not easily accomplished, particularly at the industrial scale. In this study, we introduce a room temperature clog-free solvent bonding method of PMMA using acetic acid. While acetic acid can easily dissolve PMMA, the dissolution occurs slowly and is restricted to the substrate surface due to the formation of hydrogen bonds between the carboxylic moiety of acetic acid and the methyl methacrylate monomers. In this way, a permanent seal between the PMMA substrates was realized without aggressively attacking the PMMA chemical backbone, ensuring a clog-free seal of the microchannel. Different parameters including acetic acid concentration, pressure, temperature, and bonding time were investigated to optimize the bonding performance. The reliability and robustness of the method were also demonstrated by the static leakage test and bonding of large-area and thick substrates. Surface wettability and topography were analyzed by water contact angle measurements and atomic force microscopy, respectively. The method was confirmed to be thermostable and biocompatible for polymerase chain reaction and cell culture applications, demonstrating the potential of acetic acid as a biomolecule-friendly solvent for fabricating microdevices used in bioanalytical assays. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.relation.isPartOf | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.subject | ON-A-CHIP | - |
dc.subject | DEVICES | - |
dc.subject | PLASMA | - |
dc.subject | EXTRACTION | - |
dc.subject | PAPER | - |
dc.title | Clog-free and reliable solvent bonding of poly(methyl methacrylate) microdevice mediated by eco-friendly acetic acid at room temperature and its application for polymerase chain reaction and human cell culture | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000455090000120 | - |
dc.identifier.doi | 10.1016/j.snb.2018.10.077 | - |
dc.identifier.bibliographicCitation | SENSORS AND ACTUATORS B-CHEMICAL, v.282, pp.1008 - 1017 | - |
dc.identifier.scopusid | 2-s2.0-85055625791 | - |
dc.citation.endPage | 1017 | - |
dc.citation.startPage | 1008 | - |
dc.citation.title | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.citation.volume | 282 | - |
dc.contributor.affiliatedAuthor | Trinh, Kieu The Loan | - |
dc.contributor.affiliatedAuthor | Pham, Quang Nghia | - |
dc.contributor.affiliatedAuthor | Lee, Nae Yoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Poly(methylmethacrylate) (PMMA) | - |
dc.subject.keywordAuthor | Solvent bonding | - |
dc.subject.keywordAuthor | Clog-free | - |
dc.subject.keywordAuthor | Acetic acid | - |
dc.subject.keywordAuthor | Polymerase chain reaction (PCR) | - |
dc.subject.keywordAuthor | Human umbilical vein endothelial cell (HUVEC) | - |
dc.subject.keywordPlus | ON-A-CHIP | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | EXTRACTION | - |
dc.subject.keywordPlus | PAPER | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.