石斛이 흰쥐의 뇌조직출혈에 미치는 영향Effects of Dendrobii herba against Intracerebral Hemorrhage in Rats
- Other Titles
- Effects of Dendrobii herba against Intracerebral Hemorrhage in Rats
- Authors
- 이정동; 김연섭
- Issue Date
- 2012
- Publisher
- 대한본초학회
- Keywords
- Dendrobii herba(DH); ICH; iNOS; MPO; Brain Edema
- Citation
- 대한본초학회지, v.27, no.3, pp.83 - 88
- Journal Title
- 대한본초학회지
- Volume
- 27
- Number
- 3
- Start Page
- 83
- End Page
- 88
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17361
- ISSN
- 1229-1765
- Abstract
- Objects : This study was performed in order to observe the effects of water extract of Dendrobii herba on intracerebral hemorrhage(ICH),Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. After the water extracts of Dendrobii herba were administrated orally once a day for 3 days, hematoma volume, percentage of brain edema, expression of iNOS and MPO were observed using immunohistochemistry.
Results : Rats fed with water extracts of Dendrobii herba showed reduction of hematoma volume and percentage of brain edema compared with controls. In addition, Infiltration of myeloperoxidase (MPO) expressing neutrophil and expression of inducible nitric oxide synthatase(iNOS) were significantly reduced in rats fed with water extracts of Dendrobii herba.
Conclusion : These results demonstrated that water extracts of Dendrobii herba reduced brain damage of intracerebral hemorrhage(ICH) and subsequent ICH-induced cerebral edema, and inhibited neutrophil infiltration
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